目的 探討酒石酸西尼必利片聯(lián)合胃復(fù)春片治療慢性萎縮性胃炎的臨床療效。方法 選取2018年1月—2019年3月天津中醫(yī)藥大學第一附屬醫(yī)院收治的120例慢性萎縮性胃炎患者作為研究對象，按照隨機數(shù)字表法將所有患者分為對照組和治療組，每組各60例。對照組口服胃復(fù)春片，4片/次，3次/d。治療組在對照組的基礎(chǔ)上飯前15 min口服酒石酸西尼必利片，1 mg/次，3次/d。兩組患者連續(xù)治療12周。觀察兩組臨床療效，比較兩組的臨床癥狀評分、胃黏膜炎癥病理評分、胃泌素（GAS）、胃動素（MTL）及谷胱甘肽過氧化物酶（GSH-Px）、前列腺素E₂（PGE₂）。結(jié)果 治療后，治療組的臨床總有效率為93.33%，明顯高于對照組80.00%，差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者胃脘疼痛評分、胃中嘈雜評分、噯氣泛酸評分、胃黏膜炎癥病理評分均較治療前明顯降低（P<0.05）；并且治療后治療組患者臨床癥狀評分、胃黏膜炎癥病理評分均明顯低于對照組（P<0.05）。治療后，兩組患者GAS、MTL水平均較治療前明顯降低，GSH-Px、PGE₂水平較治療前明顯升高（P<0.05）；治療后，治療組患者GAS、MTL水平明顯低于對照組，GSH-Px、PGE₂水平明顯高于對照組（P<0.05）。結(jié)論 酒石酸西尼必利片聯(lián)合胃復(fù)春片治療慢性萎縮性胃炎的療效確切，能有效改善臨床癥狀、減輕胃黏膜炎癥。

Objective To investigate the effect of Cinitapride Hydrogen Tartrate Tablets combined with Weifuchun Tablets in treatment of chronic atrophic gastritis. Methods Patients (120 cases) with chronic atrophic gastritis in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2018 to March 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Weifuchun Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Cinitapride Hydrogen Tartrate Tablets before meals for 15 min on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores, gastric mucosal inflammation pathology scores, GAS, MTL, GSH-Px, and PGE₂ in two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.33%, which was significantly higher than that of the control group (80.00%) (P<0.05). After treatment, the stomachache score, gastric noise score, belching pantothenic acid score, and gastric mucosal inflammation pathology score in two groups were significantly lower than those before treatment (P<0.05). After treatment, the clinical symptom score and gastric mucosal inflammation pathology score in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of GAS and MTL in the two groups were significantly lower than those before treatment, but the levels of GSH-Px and PGE₂ were significantly higher than those before treatment (P<0.05). After treatment, the levels of GAS and MTL in the treatment group were significantly lower than those in the control group, while the levels of GSH-Px and PGE₂ in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Cinitapride Hydrogen Tartrate Tablets combined with Weifuchun Tablets has clinical curative effect in treatment of chronic atrophic gastritis, can effectively improve the clinical symptoms, reduce the inflammation of gastric mucosa, with good clinical safety.

R975