目的 探討巖鹿乳康膠囊聯(lián)合蘆筍菠蘿蛋白酶膠囊治療乳腺增生的安全性與有效性。方法 選取2019年1月—2020年1月在河南省中醫(yī)院治療的乳腺增生患者131例，隨機(jī)分成對(duì)照組（65例）和治療組（66例）。對(duì)照組患者飯后口服蘆筍菠蘿蛋白酶膠囊，5粒/次，3次/d；治療組患者在對(duì)照組的基礎(chǔ)上飯后口服巖鹿乳康膠囊，4粒/次，3次/d，于月經(jīng)前連續(xù)服用15 d，來月經(jīng)時(shí)停用15 d。30 d為1個(gè)療程。兩組均連續(xù)治療1個(gè)療程。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者腫塊直徑，輸乳管內(nèi)徑和疼痛視覺模擬（VAS）評(píng)分，及雌二醇（E₂）、血管內(nèi)皮生長(zhǎng)因子（VEGF）、丙二醛（MDA）水平。結(jié)果 治療后，對(duì)照組臨床有效率為87.69%，顯著低于治療組的96.97%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者腫塊直徑、輸乳管內(nèi)徑，VAS評(píng)分，及血清E₂、VEGF、MDA水平均顯著降低（P<0.05），且治療組降低更顯著（P<0.05）。結(jié)論 巖鹿乳康膠囊聯(lián)合蘆筍菠蘿蛋白酶治療乳腺增生安全性高、療效顯著，且能夠顯著縮小患者乳腺腫塊和輸乳管內(nèi)徑，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the safety and efficacy of Yanlu Rukang Capsules combined with Asparagus and Bromelains Capsules in treatment of mammary hyperplasia. Methods Patients (131 cases) with mammary hyperplasia in Henan Province Hospital of TCM from January 2019 to January 2020 were randomly divided into control (65 cases) and treatment (66 cases) groups. Patients in the control group were po administered with Yanlu Rukang Capsules after meal, 5 grains/time, three times daily. Patients in the treatment group were po administered with Asparagus and Bromelains Capsules on the basis of the control group after meal, 4 grains/time, three times daily. The treatment lasted for 15 days before menstruation, and stopped taking medicine during menstruation for 15 d. 30 Days was one course of treatment. Both groups received 1 course of treatment continuously. After treatment, the clinical efficacy was evaluated, and the tumor mass diameter, lactiferous tube diameter, VAS scores, and the serum levels of E₂, VEGF, and MDA in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 87.69%, which was significantly lower than 96.97% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the tumor mass diameter, lactiferous tube diameter, VAS scores, and the serum levels of E₂, VEGF, and MDA in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Yanlu Rukang Capsules combined with Asparagus and Bromelains Capsules is safe and effective in treatment of mammary hyperplasia, can significantly reduce the tumor mass diameter and lactiferous tube diameter, which has a certain clinical application value.

R984