目的 觀察少腹逐瘀顆粒聯(lián)合布洛芬緩釋膠囊治療原發(fā)性痛經的臨床療效。方法 選取2018年2月—2020年2月濮陽市人民醫(yī)院收治的120例原發(fā)性痛經患者為研究對象，將患者按隨機數(shù)字表法分為對照組和治療組，每組各60例。對照組患者經前2～3 d開始口服布洛芬緩釋膠囊，1粒/次，2次/d。治療組在對照組治療的基礎上經前2～3 d溫水沖服少腹逐瘀顆粒，1袋/次，2次/d。兩組患者連續(xù)給藥7 d，1個月經周期為1個療程，連續(xù)給藥3個療程后觀察效果。觀察兩組的臨床療效，比較兩組的前列腺素E₂（PGE₂）、前列腺素F_2α（PGF_2α）、PGF_2α/PGE₂、人血清P物質（SP）、視覺模擬評分（VAS）、搏動指數(shù)（PI）、阻力指數(shù)（RI）、收縮期峰值/舒張期峰值（A/B）。結果 治療后，治療組患者總有效率（93.33%）明顯高于對照組（78.33%），兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組的PGE₂水平明顯升高，PGF_2α、PGF_2α/PGE₂、SP水平明顯降低，差異有統(tǒng)計學意義（P<0.05）；治療后，治療組的PGE₂水平明顯高于對照組，PGF_2α、PGF_2α/PGE₂、SP水平明顯低于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組患者VAS評分均明顯降低，差異具有統(tǒng)計學意義（P<0.05）；治療后，治療組患者VAS評分明顯低于對照組，差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者PI、RI、A/B均明顯降低，差異具有統(tǒng)計學意義（P<0.05）；治療后，治療組患者PI、RI、A/B均低于對照組，差異有統(tǒng)計學意義（P<0.05）。結論 少腹逐瘀顆粒聯(lián)合布洛芬緩釋膠囊治療原發(fā)性痛經具有較好的臨床療效，可以減輕患者疼痛程度，改善患者子宮動脈血流動力學和血清因子水平。

Objective To observe the clinical efficacy of Shaofu Zhuyu Granules combined with Ibuprofen Sustained-release Capsules in treatment of primary dysmenorrhea. Methods Patients (120 cases) with primary dysmenorrhea in Puyang People’s Hospital from February 2018 to February 2020 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Ibuprofen Sustained-release Capsules before menstruation for 2 — 3 d, 1 grain/time, once daily. Patients in the treatment group were po administered with Shaofu Zhuyu Granules before menstruation for 2 — 3 d on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 7 d, and one menstrual cycle was a course of treatment, and three courses were given continuously. After treatment, the clinical efficacies were evaluated, and PGE₂, PGF_2α, PGF_2α/PGE₂, SP, VAS, PI, RI, and A/B in two groups were compared. Results After treatment, the total effective rate of the treatment group (93.33%) was significantly higher than that of the control group (78.33%), and the difference between two groups was statistically significant (P<0.05). After treatment, the levels of PGE₂ in the two groups were significantly increased, but the levels of PGF_2α, PGF_2α/PGE₂ and SP were significantly decreased (P<0.05). After treatment, the level of PGE₂ in the treatment group was significantly higher than that in the control group, but the levels of PGF_2α, PGF_2α/PGE₂, and SP in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the VAS scores of two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the VAS score of the treatment group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). After treatment, PI, RI, and A/B of two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, PI, RI, and A/B of the treatment group were lower than those of the control group, and the difference was statistically significant (P<0.05). Conclusion Shaofu Zhuyu Granules combined with Ibuprofen Sustained-release Capsules has clinical curative effect in treatment of primary dysmenorrhea, can reduce the pain degree of patients, improve the uterine artery hemodynamics and serum factor levels.

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