目的 分析咸陽市第一人民醫(yī)院近3年出院患者碳青霉烯類抗菌藥物應(yīng)用情況，為該類抗菌藥物的管理及臨床合理應(yīng)用提供參考。方法 回顧性分析咸陽市第一人民醫(yī)院2017年1月1日—2019年12月31日出院的475例應(yīng)用碳青霉烯類抗菌藥物患者的病案資料，對患者的基本信息、用藥科室、患者感染部位、用法用量、送檢情況以及適應(yīng)癥等運用WPS 2020進(jìn)行統(tǒng)計分析。結(jié)果 用藥數(shù)量：美羅培南 > 亞胺培南-西司他丁 > 比阿培南。用藥科室分布：呼吸與危重癥醫(yī)學(xué)科第一、中心ICU第二，其余科室相對較少。藥物用法：靜脈滴注473例，超聲透藥2例。藥物用量：91例劑量不足，47例劑量過高。聯(lián)合用藥情況：與抗菌藥物聯(lián)用195例，與丙戊酸鈉聯(lián)用6例。病原學(xué)送檢率88.84%。適應(yīng)癥：48例為無適應(yīng)癥用藥。結(jié)論 咸陽市第一人民醫(yī)院碳青霉烯類抗菌藥物臨床應(yīng)用合理性有待提高，合理應(yīng)用抗菌藥物可節(jié)約部分醫(yī)療花費。

Objective To analyze the application of carbapenem antibiotics in the First People's Hospital of Xianyang in recent three years, to provide reference for the management and clinical rational application of carbapenems antibiotics. Methods The medical records of 475 patients with carbapenem antibiotics who were discharged from the First People's Hospital of Xianyang from 1st January 2018 to 31th December 2019 were retrospectively analyzed. WPS 2020 was used to analyze the basic information, medication department, infection site, usage and dosage, submission and indications of patients. Results Quantity: Meropenem > imipenem cilastatin > biapenem. Department distribution: the first is Department of Respiratory and Critical Care Medicine, and second is ICU, other departments are relatively few. Drug usage: 473 cases patients were administrated by intravenous drip, and 2 cases patients were administrated by transdermal ultrasound. Drug dosage: 91 cases were gived with insufficient dose drug, and 47 cases were gived with over dose drug. Combination of drugs: 195 cases were treated with antibiotics, and 6 cases were treated with sodium valproate. Etiological examination rate: 88.84%. Indications: 48 cases were judged to have no indication. Conclusion The rationality of clinical application of carbapenem antibiotics in the First People's Hospital of Xianyang needs to be improved, and rational use of antibiotics antibiotics can save part of the medical expenses.

R978.1