在以聚乳酸–乙醇酸共聚物（PLGA）為輔料的藥物緩控釋制劑中，藥物的釋放行為主要取決于PLGA聚合物的降解行為。PLGA的降解行為受骨架結(jié)構(gòu)、環(huán)境因素和劑型因素等影響。對PLGA的降解機制進行剖析，并綜述影響PLGA降解行為的相關(guān)因素，包括PLGA的單體聚乳酸與聚乙醇酸的比例、相對分子質(zhì)量、pH值、結(jié)晶度、溫度、藥物的類型和基質(zhì)包封藥物后的劑型等，同時論述了其對緩控釋制劑藥物釋放行為的影響。

In the drug sustained and controlled release preparations with polylactic acid-glycolic acid copolymer (PLGA) as excipients, the drug release behavior mainly depends on the degradation behavior of PLGA polymer. The degradation behavior of PLGA is affected by the skeleton structure, environmental factors and dosage form factors. In this paper, the degradation mechanism of PLGA was analyzed, and the related factors affecting the degradation behavior of PLGA were systematically reviewed, including the ratio of PLGA monomer polylactic acid and polyglycolic acid, relative molecular weight, pH value, crystallinity, temperature, drug type and dosage form after drug encapsulated by matrix, and its effect on the drug release behavior of sustained and controlled release preparations was discussed.

R944