目的 探討蜂膠牙泰聯(lián)合米諾環(huán)素治療急性牙周炎的臨床效果。方法 選取2018年6月-2020年6月上海市嘉定區(qū)安亭醫(yī)院收治的90例急性牙周炎患者（121顆患牙），隨機(jī)分成對照組（45例，62顆患牙）和治療組（45例，59顆患牙）。對照組口服鹽酸米諾環(huán)素片，50 mg/次，2次/d。治療組在對照組的基礎(chǔ)上給予蜂膠牙泰，1次/d。兩組患者均連續(xù)治療3 d。觀察兩組臨床療效，比較治療前后兩組患者牙周袋深度、菌斑指數(shù)，齦溝液前列腺素E2（PGE2）、基質(zhì)金屬蛋白酶-9（MMP-9）和血管內(nèi)皮生長因子（VEGF）水平，疼痛視覺模擬量表（VAS）評分和血清C反應(yīng)蛋白（CRP）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-1β（IL-1β）水平。結(jié)果 治療后，治療組總有效率為95.16%，較對照組的79.66%顯著提高（P<0.05）。治療后，兩組牙周袋深度均較治療前顯著變淺，菌斑指數(shù)則均顯著降低（P<0.05）；且與對照組比較，治療組牙周袋水平顯著更淺，菌斑指數(shù)顯著更低（P<0.05）。治療后，兩組齦溝液PGE2、MMP-9、VEGF水平均較本組治療前顯著降低（P<0.05），但治療組下降更顯著（P<0.05）。治療后，兩組疼痛VAS評分和血清CRP、TNF-α、IL-1β濃度均顯著降低（P<0.05），但治療組比對照組降低作用更顯著（P<0.05）。結(jié)論 蜂膠牙泰聯(lián)合米諾環(huán)素治療急性牙周炎的總體療效滿意，可安全有效地改善患者臨床癥狀及牙周組織狀況，明顯減輕患者牙周組織局部及全身炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Fengjiao Yatai combined with minocycline in treatment of acute periodontitis. Methods Patients (121) with acute periodontitis in Anting Hospital of Jiading District in Shanghai from June 2018 to June 2020 were randomly divided into control (45 cases, 62 teeth) and treatment (45 cases, 59 teeth) groups. Patients in the control group were po administered with Minocycline Hydrochloride Tablets, 50 mg/time, twice daily. Patients in the treatment group were administered with Fengjiao Yatai on the basis of the control group, once daily. Patients in two groups were treated for 3 d. After treatment, the clinical efficacy was evaluated, and the periodontal pocket depth, plaque index, PGE2, MMP-9, and VEGF levels in gingival crevicular fluid, VAS scores, the serum levels of CRP, TNF-α, and IL-1β in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 95.16%, which was significantly higher than that of the control group (79.66%) (P<0.05). After treatment, the depth of periodontal pocket in both groups was significantly shallower than that before treatment, but the plaque index was significantly decreased (P<0.05), and the periodontal pocket depth in the treatment group was significantly shallower than that in the control group, Plaque index was significantly lower (P<0.05). After treatment, the contents of PGE2, MMP-9 and VEGF in gingival crevicular fluid of the two groups were significantly lower than those before treatment (P<0.05), but the decrease was more significant in the treatment group (P<0.05). After treatment, the VAS score of pain and the concentration of serum CRP, TNF-α and IL-1β in both groups decreased significantly (P<0.05), but the effect in the treatment group was more significant than that in the control group (P<0.05). Conclusion The overall curative effect of Fengjiao Yatai combined with minocycline in treatment of acute periodontitis is satisfactory, which can safely and effectively improve the clinical symptoms and periodontal tissue condition, and significantly reduce the local and systemic inflammatory reaction of periodontal tissue, which has a certain clinical application value.

R988.2

上海市衛(wèi)生健康委員會衛(wèi)生行業(yè)臨床研究課題（20184Y0189）