目的 探討柴芩清寧膠囊聯(lián)合利巴韋林治療急性上呼吸道感染的臨床療效。方法 選取2019年7月—2020年7月在中國人民武裝警察部隊(duì)特色醫(yī)學(xué)中心進(jìn)行治療的98例急性上呼吸道感染患者為研究對象，根據(jù)用藥的差別分為對照組（49例）和治療組（49例）。對照組靜脈滴注利巴韋林注射液，0.5 g/次，2次/d，同0.9%氯化鈉注射液100 mL配伍。治療組在對照組基礎(chǔ)上口服柴芩清寧膠囊，3粒/次，3次/d。兩組均治療7 d。觀察兩組的臨床療效，比較兩組臨床癥狀消失時間和血清因子水平的變化情況。結(jié)果 經(jīng)治療，治療組的總有效率97.96%，顯著高于對照組的83.67%（P<0.05）。經(jīng)治療，治療組體溫恢復(fù)正常時間、咽痛消失時間、咳嗽消失時間、鼻卡他/鼻塞消失時間均顯著短于對照組（P<0.05）。經(jīng)治療，兩組血清超敏C反應(yīng)蛋白（hs-CRP）、淀粉樣蛋白A（SAA）、半胱氨酰白三烯（CYSLTS）、白細(xì)胞介素-17（IL-17）、巨噬細(xì)胞遷移抑制因子（MIF）水平均顯著降低（P<0.05）；治療后，治療組患者這些血清學(xué)指標(biāo)顯著低于對照組（P<0.05）。結(jié)論 柴芩清寧膠囊聯(lián)合利巴韋林治療急性上呼吸道感染患者不僅可促進(jìn)臨床癥狀恢復(fù)，還可顯著降低機(jī)體炎癥因子水平，具有很好的臨床價值。

Objective To investigate the clinical efficacy of Chaiqin Qingning Capsules combined with ribavirin in treatment of acute upper respiratory tract infection. Methods Patients (98 cases) with acute upper respiratory tract infection in Characteristic Medical Center of Chinese People's Armed Police Force from July 2019 to July 2020 were divided into control and treatment groups according to different medication regimens, and each group had 49 cases. Patients in the control group were iv administered with Ribavirin Injection, 0.5 g/time, twice daily, with 0.9% sodium chloride injection 100 mL. Patients in the treatment group were po administered with Chaiqin Qingning Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in tw o groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, disappearance time of clinical symptom and the change of serum factors between two groups were compared. Results After treatment, the total effective rate of treatment group was 97.96%, which was significantly higher than that of control group (83.67%, P<0.05). After treatment, the recovery time of body temperature, disappearance time of pharyngeal pain, disappearance time of cough and disappearance time of nasal catal/nasal obstruction in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the serum levels of hypersensitive C-reactive protein (hs-CRP), amyloid A (SAA), CYSLTS, interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF) were significantly decreased in both groups (P<0.05). After treatment, these serological indexes in treatment group were significantly lower than those in control group (P<0.05). Conclusion Chaiqin Qingning Capsules combined with ribavirin in treatment of acute upper respiratory tract infection can not only promote the recovery of clinical symptoms, but also significantly reduce the level of inflammatory factors in the body, which has a good clinical value.

R974

天津市科技計(jì)劃項(xiàng)目（17JCTPJC63400）