目的 探討鼻竇炎口服液聯(lián)合布地奈德吸入氣霧劑治療急性鼻竇炎的臨床療效。方法 選取2019年6月—2020年9月濮陽市油田總醫(yī)院收治的88例急性鼻竇炎患者，按照隨機(jī)數(shù)字表法將88例患者分為對(duì)照組和治療組，每組44例。對(duì)照組霧化吸入布地奈德吸入氣霧劑，2 mL/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服鼻竇炎口服液，10 mL/次，3次/d。兩組患者連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組患者臨床癥狀的改善時(shí)間，檢測(cè)兩組患者血清中炎性因子水平。結(jié)果 治療后，治療組總有效率為88.64%，對(duì)照組為70.45%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組的鼻塞、流涕、頭痛消失時(shí)間短于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的白細(xì)胞介素-6（IL-6）、白細(xì)胞介素-1β（IL-1β）、嗜酸性粒細(xì)胞陽離子蛋白（ECP）水平明顯降低（P<0.05）；且治療后治療組的IL-6、IL-1β、ECP水平比對(duì)照組低，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 鼻竇炎口服液聯(lián)合布地奈德吸入氣霧劑可提高急性鼻竇炎的療效，減輕臨床癥狀，降低炎癥介質(zhì)水平，且安全性良好。

Objective To investigate the clinical effect of Bidouyan Oral Lliquid combined with Budesonide Inhalation Aerosol in treatment of acute sinusitis. Methods Patients (88 cases) with acute sinusitis in Puyang Oilfield General Hospital from June 2019 to September 2020 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were atomization inhalation with Budesonide Inhalation Aerosol, 2 mL/time, once daily. Patients in the treatment group were po administered with Bidouyan Oral Lliquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the improvement times of the main clinical symptoms of the two groups were compared, and the levels of inflammatory factors in the serum of the two groups were detected. Results After treatment, the total effective rate was 88.64% in the treatment group and 70.45% in the control group, and the difference was statistically significant (P<0.05). After treatment, the disappearance times of nasal congestion, runny nose and headache in the treatment group were shorter than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of IL-6, IL-1β, and ECP in two groups were significantly decreased (P<0.05). After treatment, the levels of IL-6, IL-1β and ECP in the treatment group were lower than those in the control group, the difference was statistically significant (P<0.05). Conclusion Bidouyan Oral Lliquid combined with Budesonide Inhalation Aerosol can improve the curative effect of acute sinusitis, relieve clinical symptoms and reduce the level of inflammatory factors, with good safety.

R974

河南省中醫(yī)藥科學(xué)研究專項(xiàng)課題（20182Y2093）