腦梗死是多種腦血管病變引起腦部血液供應(yīng)出現(xiàn)障礙，使腦組織缺血或者缺氧性壞死，進而引起的一系列神經(jīng)功能缺損綜合征。近年來我國腦梗死的發(fā)病率逐年升高，致死率、致殘率均極高，嚴重危害人們的身心健康。臨床對于腦梗死損傷的研究頗多，可能與氧化應(yīng)激、炎癥、鈣超載、凋亡等有關(guān)。柚皮苷是一種天然黃酮類化合物，具有抗氧化應(yīng)激、抗炎、減輕鈣離子超載、抗細胞凋亡作用，能夠?qū)δX組織起到有效的保護作用，改善患者的預(yù)后情況。因此對柚皮苷的腦梗死保護作用的機制進行綜述。

Cerebral infarction is a series of neurological deficit syndromes caused by a variety of cerebrovascular diseases that cause the injured blood supply to the brain, which makes the brain tissue ischemia or hypoxic necrosis. In recent years, the cerebral infarction in our country has been increasing year by year with extremely high fatality rate and disability rate, which seriously endangers people's physical and mental health. There have been many clinical studies on the secondary injury of cerebral infarction, which may be related to oxidative stress, inflammation, calcium overload, and apoptosis. Naringin is a natural flavonoid compound, which has the effects of anti-oxidative stress, anti-inflammatory, reducing calcium ion overload, and anti-apoptosis. Naringin can effectively protect brain tissue and improve the prognosis of patients. Therefore, the paper discusses the protective effect of naringin on cerebral infarction and its possible mechanism.

R971

國家自然科學(xué)基金資助項目（11672332）