目的 探討益血生膠囊聯(lián)合多糖鐵復(fù)合物膠囊治療妊娠期缺鐵性貧血的臨床療效。方法 選取2018年8月—2020年8月在南陽市中心醫(yī)院進行治療的158例妊娠期缺鐵性貧血患者為研究對象，根據(jù)用藥差別分為對照組（79例）和治療組（79例）。對照組口服多糖鐵復(fù)合物膠囊，0.3 g/次，1次/d；治療組在對照組基礎(chǔ)上口服益血生膠囊，1 g/次，3次/d。兩組患者均治療4周對比臨床效果。觀察兩組的臨床療效，比較兩組患者鐵代謝指標、血常規(guī)指標和血清學(xué)指標的變化情況。結(jié)果 經(jīng)治療，治療組總有效率是98.73%，顯著高于對照組的86.08%（P<0.05）。治療后，兩組血清鐵蛋白（SF）、血清鐵（SI）均增高，但轉(zhuǎn)鐵蛋白受體（sTFR）、總鐵結(jié)合力（TIBC）均顯著降低（P<0.05）；治療后，治療組鐵代謝指標改善優(yōu)于對照組（P<0.05）。治療后，兩組紅細胞計數(shù)（RBC）、血紅蛋白（Hb）、紅細胞平均體積（MCV）、平均血紅蛋白量（MCH）均較治療前顯著增高（P<0.05）；治療后，治療組血常規(guī)指標改善優(yōu)于對照組（P<0.05）。治療后，兩組血清白細胞介素2（IL-2）、γ干擾素（INF-γ）、氧磷酶1（PON1）、鐵調(diào)素-25水平均顯著升高（P<0.05）；治療后，治療組血清學(xué)指標改善優(yōu)于對照組（P<0.05）。結(jié)論 益血生膠囊聯(lián)合多糖鐵復(fù)合物膠囊治療妊娠期缺鐵性貧血效果顯著，可有效改善患者貧血狀態(tài)，改善鐵代謝指標和血清細胞因子水平，有著良好的臨床應(yīng)用價值。

Objective To investigate the clinical efficacy of Yixuesheng Capsules combined with iron polysaccharide complex in treatment of iron deficiency anemia during pregnancy. Methods A total of 158 patients with iron deficiency anemia during pregnancy who were treated in Nanyang Central Hospital from August 2018 to August 2020 were selected as the research subjects, and they were divided into control group (79 cases) and treatment group (79 cases) according to medication difference. Patients in the control group were po administered with Iron Polysaccharide Complex Capsules, 0.3 g/time, once daily. Patients in the treatment group were po administered with Yixuesheng Capsules on the basis of the control group, 1 g/time, three times daily. Two groups of patients were treated for 4 weeks. The clinical efficacy of the two groups was observed and the changes of iron metabolism indexes, blood routine indexes, and serological indexes were compared between two groups. Results After treatment, the total effective rate of treatment group was 98.73%, which was significantly higher than that of control group (86.08%, P<0.05). After treatment, SF and SI were increased in both groups, but sTFR and TIBC were significantly decreased (P<0.05). After treatment, the improvement of iron metabolism in the treatment group was better than that in the control group (P<0.05). After treatment, the levels of RBC, Hb, MCV, and MCH in two groups were significantly increased compared with before treatment (P<0.05). After treatment, the improvement of blood routine indexes in treatment group was better than that in control group (P<0.05). After treatment, the levels of serum IL-2, INF-γ, PON1, and iron-modulin-25 in two groups were significantly increased (P<0.05). After treatment, the improvement of serological indexes in the treatment group was better than that in the control group (P<0.05). Conclusion Yixuesheng Capsules combined with iron polysaccharide complex has significantly effective in treatment of iron deficiency anemia during pregnancy, and can effectively improve the anemia status of patients, and also can improve iron metabolism indexes and serum cytokine levels, which has good clinical application value.

R984

河南省科技攻關(guān)項目（201702564）