目的 探討生血寶顆粒聯(lián)合乳酸亞鐵片治療兒童缺鐵性貧血的臨床療效。方法 選取2019年9月—2020年11月在信陽市中心醫(yī)院就診的86例缺鐵性貧血患兒作為研究對象，按照隨機數(shù)字表法將86例患者分為對照組和治療組，每組各43例。對照組口服乳酸亞鐵片，0.1 g/次，3次/d。治療組在對照組治療基礎(chǔ)上溫水沖服生血寶顆粒，8 g/次，2次/d。兩組患兒連續(xù)治療8周。觀察兩組臨床療效，比較兩組治療前后的世界衛(wèi)生組織生存質(zhì)量測定量表簡表（WHOQOL-BREF）評分、紅細(xì)胞指標(biāo)和鐵代謝指標(biāo)。結(jié)果 治療后，治療組患者的總有效率為95.35%，對照組為81.40%，組間比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的WHOQOL-BREF評分顯著升高（P<0.05），以治療組WHOQOL-BREF評分升高更明顯（P<0.05）。治療后，兩組的紅細(xì)胞計數(shù)、血紅蛋白、網(wǎng)織紅細(xì)胞顯著升高（P<0.05）；治療后治療組的紅細(xì)胞計數(shù)、血紅蛋白、網(wǎng)織紅細(xì)胞比對照組高，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組鐵、鐵蛋白（SF）、轉(zhuǎn)鐵蛋白飽和度（TS）水平顯著升高（P<0.05）；治療后，治療組患者的鐵、SF、TS水平高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 生血寶顆粒聯(lián)合乳酸亞鐵片治療缺鐵性貧血的療效確切，能提高患兒的生活質(zhì)量，改善紅細(xì)胞水平和鐵代謝水平。

Objective To explore the clinical study of Shengxuebao Granules combined with Ferrous Lactate Tablets in treatment of iron deficiency anemia in children. Methods Children (86 cases) with iron deficiency anemia in Xinyang Central Hospital from September 2019 to November 2020 were randomly divided into control and treatment groups, and each group had 43 cases. Children in the control group were po administered with Ferrous Lactate Tablets, 0.1 g/time, three times daily. Children in the treatment group were po administered with Shengxuebao Granules on the basis of the control group, 0.8 g/time, twice daily. Children in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and WHOQOL-BREF score, red blood cell index, and iron metabolism index in two groups were compared before and after treatment. Results After treatment, the total effective rate of the treatment group was 95.35%, and that of the control group was 81.40%, and the difference was statistically significant (P<0.05). After treatment, the WHOQOL-BREF scores of two groups was significantly increased (P<0.05), and the WHOQOL-BREF score in the treatment group was significantly higher than that of the control group (P<0.05). After treatment, the red blood cell count, hemoglobin, and reticulocyte of two groups were significantly increased (P<0.05). After treatment, the red blood cell count, hemoglobin, and reticulocyte of the treatment group were higher than those of the control group (P<0.05). After treatment, the levels of iron, SF, and TS in two groups were significantly increased (P<0.05). After treatment, the levels of iron, SF, and TS in the treatment group were higher than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Shengxuebao Granules combined with Ferrous Lactate Tablets has curative effect in the treatment of iron deficiency anemia, can improve the level of red blood cell and iron metabolism, improve the quality of life of children.

R985

信陽市市級軟科學(xué)項目（20190056）