目的 探討七味肝膽清顆粒聯(lián)合注射用頭孢哌酮鈉舒巴坦鈉治療慢性膽囊炎的臨床療效。方法 選取2018年2月—2020年2月天津港口醫(yī)院收治的184例慢性膽囊炎患者，按照隨機(jī)數(shù)字表法將全部患者分為對(duì)照組和治療組，每組各包括92例。對(duì)照組靜脈滴注注射用頭孢哌酮鈉舒巴坦鈉，4.0 g加入5%葡萄糖注射液100 mL中，2次/d。治療組在對(duì)照組基礎(chǔ)上溫水沖服七味肝膽清顆粒，1.6 g/次，2次/d。兩組患者連續(xù)治療2周。觀察兩組患者的總有效率，比較兩組患者主要癥狀消失時(shí)間、膽囊功能指標(biāo)和血清炎癥指標(biāo)水平。結(jié)果 治療后，治療組患者的總有效率為90.22%，對(duì)照組的總有效率為79.35%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組的退熱時(shí)間、腹痛消失時(shí)間、惡心消失時(shí)間比對(duì)照組短，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的膽囊收縮率明顯升高，膽囊壁厚度明顯降低，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組的膽囊收縮率高于對(duì)照組，膽囊壁厚度低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）、降鈣素原（PCT）水平顯著降低，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組的CRP、IL-6、PCT水平比對(duì)照組低，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 七味肝膽清顆粒聯(lián)合注射用頭孢哌酮鈉舒巴坦鈉可提高慢性膽囊炎的臨床療效，改善臨床癥狀，降低炎癥反應(yīng)，且安全性良好。

Objective To investigate the clinical efficacy of Qiwei Gandanqing Granules combined with Cefoperazone Sodium and Sulbactam Sodium for injection in treatment of chronic cholecystitis. Methods Patients (184 cases) with chronic cholecystitis in Tianjin Port Hospital from February 2018 to February 2020 were divided into control and treatment groups according to the method of random number table, and each group had 92 cases. Patients in the control group were iv administered with Cefoperazone Sodium and Sulbactam Sodium for injection, 4.0 g added into 5% glucose solution 100 mL, twice daily. Patients in the treatment group were po administered with Qiwei Gandanqing Granules on the basis of the control group, 1.6 g/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and main symptoms disappear times, gallbladder function indexes, and serum inflammation indexes levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 90.22%, and that of the control group was 79.35%, and the difference was statistically significant (P < 0.05). After treatment, the antipyretic time, abdominal pain disappearance time, and nausea disappearance time of the treatment group were shorter than those of the control group, and the difference was statistically significant (P < 0.05). After treatment, the gallbladder contraction rate of two groups were significantly increased, but the gallbladder wall thickness of two groups were significantly decreased (P < 0.05). And the gallbladder contraction rate of the treatment group was higher than that of the control group, but the gallbladder wall thickness of the treatment group was lower than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of CRP, IL-6, and PCT in two groups were significantly decreased, and the difference was statistically significant (P < 0.05). And the levels of CRP, IL-6, and PCT in the treatment group were lower than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion Qiwei Gandanqing Granules combined with Cefoperazone Sodium and Sulbactam Sodium for injection can improve the clinical efficacy of chronic cholecystitis, improve clinical symptoms, reduce inflammatory reaction, with good safety.

R975

天津醫(yī)科大學(xué)總醫(yī)院青年孵育基金項(xiàng)目（2YYFY2016021）