目的 探討尪痹片聯(lián)合雙醋瑞因治療膝骨關(guān)節(jié)炎的臨床療效。方法 選取2018年9月—2020年9月在新鄉(xiāng)醫(yī)學(xué)院第一附屬醫(yī)院治療的106例膝骨關(guān)節(jié)炎患者，根據(jù)隨機(jī)數(shù)字表法分為對照組和治療組，每組各53例。對照組餐后口服雙醋瑞因膠囊，1粒/次，1～2次/d。治療組在對照組基礎(chǔ)上口服尪痹片，4片/次，3次/d。兩組患者均治療2個(gè)月。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀緩解時(shí)間、VSA評分、WOMAS評分，血清白細(xì)胞介素6（IL-6）、白細(xì)胞介素-1β（IL-1β）、腫瘤壞死因子α（TNF-α）和超敏C反應(yīng)蛋白（hs-CRP）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組臨床療效明顯高于對照組（P<0.05）。治療后，治療組關(guān)節(jié)疼痛、關(guān)節(jié)晨僵、關(guān)節(jié)腫脹緩解時(shí)間均明顯早于對照組（P<0.05）。治療1、4、8周后，兩組VAS評分和WOMAS評分均顯著降低（P<0.05）；且治療后治療組患者VAS評分和WOMAS評分均明顯低于對照組（P<0.05）。治療后，兩組患者血清炎性因子IL-6、IL-1β、TNF-α、hs-CRP水平均明顯降低（P<0.05），且治療組明顯低于對照組（P<0.05）。治療組藥物不良反應(yīng)總發(fā)生率明顯低于對照組（P<0.05）。結(jié)論 尪痹片與雙醋瑞因聯(lián)合治療膝骨關(guān)節(jié)炎，臨床效果顯著，能有效減輕關(guān)節(jié)疼痛及降低炎癥反應(yīng)，促進(jìn)關(guān)節(jié)功能的恢復(fù)。

Objective To investigate the curative effect of Wangbi Tablets combined with diacerein in treatment of knee osteoarthritis. Methods Patients (106 cases) with knee osteoarthritis in the First Affiliated Hospital of Xinxiang Medical University from September 2018 to September 2020 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Diacerein Capsules, 1 grains/time, 1 — 2 times/daily. Patients in the treatment group were po administered with Wangbi Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the relief time of clinical symptom, VSA scores, WOMAS scores, serum inflammatory factor of IL-6, IL-1β, TNF-α, and hs-CRP levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effect of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the relief time of joint pain, morning stiffness and joint swelling in the treatment group was significantly earlier than that in the control group (P < 0.05). After 1, 4, and 8 weeks of treatment, VAS score and WOMAS score were significantly decreased in both groups (P < 0.05). After treatment, the scores of VSA and WOMAS in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-6, IL-1β, TNF-α, and hs-CRP in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). The total incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion The clinical effect of Wangbi Tablets combined with diacerein in treatment of knee osteoarthritis is remarkable, which can effectively relieve joint pain, reduce inflammatory reaction, and promote the recovery of joint function.

R977

河南省衛(wèi)生健康委員會項(xiàng)目（豫衛(wèi)科教函[2020]30號）