目的 探討棗仁安神膠囊聯(lián)合阿立哌唑對精神分裂癥患者血清神經(jīng)遞質、認知功能、生活質量的影響。方法 選取2019年5月—2020年10月黃石市精神病醫(yī)院收治的82例精神分裂癥患者，根據(jù)隨機數(shù)字表法將82例患者分為對照組和治療組，每組各41例。對照組口服阿立哌唑片，15 mg/次，2次/d。治療組在對照組基礎上口服棗仁安神膠囊，5粒/次，每日睡前1次。兩組均連續(xù)治療2個月。觀察兩組的臨床療效，比較兩組陽性與陰性癥狀量表（PANSS）評分、蒙特利爾認知評估量表（MoCA）評分、生活質量綜合評定量表（GQOLI-74）評分和神經(jīng)遞質的變化情況。結果 治療后，治療組總有效率為95.12%顯著高于對照組的80.49%（P<0.05）。治療后，兩組陽性癥狀評分、陰性癥狀評分、一般精神病理癥狀和PANSS總分均顯著降低（P<0.05）；且治療后治療組PANSS評分顯著低于對照組（P<0.05）。治療后，兩組MoCA評分、GQOLI-74評分均較治療前顯著提高（P<0.05）；且治以治療組升高更明顯（P<0.05）。治療后，兩組5-羥吲哚乙酸（5-HIAA）、γ-氨基丁酸（GABA）、神經(jīng)生長因子（NGF）均較治療前顯著升高（P<0.05）；且治療后治療組神經(jīng)遞質水平高于對照組（P<0.05）。結論 棗仁安神膠囊聯(lián)合阿立哌唑治療精神分裂癥具有較好的臨床療效，可調節(jié)患者血清神經(jīng)遞質的分泌，進一步改善認知功能和生活質量，具有一定的臨床應用價值。

Objective To investigate the effect of Zaoren Anshen Capsules combined with aripiprazole on serum neurotransmitter, cognitive function and life quality in patients with schizophrenia. Methods A total of 82 patients with schizophrenia admitted to Huangshi Psychiatric Hospital from May 2019 to October 2020 were divided into control group and treatment group according to random number table method, with 41 patients in each group. Patients in the control group were po administered with Aripiprazole Tablets, 15 mg/time, twice daily. Patients in the treatment group were po administered with Zaoren Anshen Capsules on the basis of the control group, 5 grains/time, once daily before going to bed. Both groups were treated continuously for 2 months. The clinical efficacy of the two groups was observed. The scores of Positive and Negative Symptomatic Scale (PANSS), Montreal Cognitive Assessment Scale (MOCA), Comprehensive Quality of Life Scale (GQOLI-74) and the changes of neurotransmitters were compared between the two groups. Results After treatment, the total effective rate of 95.12% in treatment group, which was significantly higher than that of control group (80.49%, P < 0.05). After treatment, the positive symptom score, negative symptom score, general psychopathological symptom score and PANSS total score in both groups were significantly decreased (P < 0.05). After treatment, PANSS scores in treatment group were significantly lower than those in control group (P < 0.05). After treatment, MOCA score and GQOLI-74 score in two groups was significantly increased compared with before treatment (P < 0.05). The increase was more significant in the treatment group (P < 0.05). After treatment, 5-hydroxyindole acetic acid (5-HIAA), γ-aminobutyric acid (GABA) and nerve growth factor (NGF) were significantly increased in both groups compared with before treatment. After treatment, the neurotransmitter level in treatment group was higher than that in control group (P < 0.05). Conclusion Zaoren Anshen Capsules combined with Aripiprazole has a good clinical effect in the treatment of schizophrenia, and can regulate the secretion of serum neurotransmitters, further improve cognitive function and life quality, which has certain clinical application value.

R971