目的 探討金蕎麥片聯(lián)合茶堿緩釋片治療老年慢性支氣管炎的療效及對血清學(xué)指標(biāo)的影響。方法 回顧性分析2020年2月—2020年11月在天津市濱海新區(qū)大港醫(yī)院進(jìn)行治療的94例老年慢性支氣管炎患者，根據(jù)所用藥物的區(qū)別將所有患者分為對照組和治療組，每組各47例。對照組口服茶堿緩釋片，0.2 g/次，2次/d；治療組在對照組基礎(chǔ)上口服金蕎麥片，5片/次，3次/d。兩組均治療2周進(jìn)行效果比較。觀察兩組的臨床療效，比較兩組臨床癥狀改善時(shí)間、炎癥介質(zhì)和肺功能指標(biāo)。結(jié)果 經(jīng)治療，治療組總有效率是97.87%，顯著高于對照組的82.98%（P<0.05）。經(jīng)治療，治療組咳嗽、氣喘、咳痰癥狀改善時(shí)間均短于對照組（P<0.05）。經(jīng)治療，兩組血清血清降鈣素原（PCT）、巨噬細(xì)胞炎癥蛋白-1α（MIP-1α）、腫瘤壞死因子-α（TNF-α）、巨噬細(xì)胞刺激蛋白（MSP）、白細(xì)胞介素-6（IL-6）水平均較治療前顯著下降（P<0.05）；且治療后治療組炎癥介質(zhì)水平顯著低于對照組（P<0.05）。經(jīng)治療，兩組第一秒用力呼氣容積（FEV1）、第一秒用力呼氣量占用力肺活量比值（FEV1/FVC）、FEV1占預(yù)計(jì)值百分比（FEV1%）均上升（P<0.05），并以治療組升高更顯著（P<0.05）。結(jié)論 金蕎麥片聯(lián)合茶堿緩釋片治療老年慢性支氣管炎具有較好的臨床療效，不僅可促進(jìn)患者臨床癥狀改善，還促進(jìn)患者肺功能及血清炎性因子水平改善，有著良好臨床應(yīng)用價(jià)值。

Objective To investigate the effect of Jinqiaomai Tablets combined with Theophylline Sustained-release Tablets in treatment of senile chronic bronchitis and its influence on serological indexes. Methods Retrospective analysis was performed on 94 elderly patients with chronic bronchitis who were treated in Dagang Hospital of Binhai New District, Tianjin from February 2020 to November 2020. All patients were divided into control group and treatment group according to the difference of drugs used, with 47 cases in each group. Patients in the control group were po administered with Theophylline Sustained-release Tablets, 0.2 g/time, twice daily. Patients in the treatment group were po administered with Jinqiaomai Tablets on the basis of the control group, 5 tablets/time, three times daily. The clinical efficacy of the two groups was observed, and the improvement time of clinical symptoms, inflammatory mediators and pulmonary function indexes of the two groups were compared. Results After treatment, the total effective rate of treatment group was 97.87%, which was significantly higher than that of control group (82.98%, P < 0.05). After treatment, the symptom improvement time of cough, asthma, and expectoration in treatment group was shorter than that in control group (P < 0.05). After treatment, the serum levels of PCT, macrophage inflammatory protein-1α (MIP-1α), tumor necrosis factor-α (TNF-α), macrophage stimulating protein (MSP), and interleukin-6 (IL-6) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the level of inflammatory mediators in treatment group were significantly lower than that in control group (P < 0.05). After treatment, FEV1, FEV1/FVC, and FEV1% were increased in both groups(P < 0.05), and the increase was more significant in the treatment group (P < 0.05). Conclusion Jinqiaomai Tablets combined with Theophylline Sustained-release Tablets has good clinical effect in treatment of senile chronic bronchitis, not only can promote the improvement of patients' clinical symptoms, but also promote the improvement of patients' lung function and serum inflammatory factor level, which has good clinical application value.

R974