伏立康唑是多種深部真菌感染的有效治療藥物，但其藥動學復雜、治療窗窄、個體差異大，且其血藥濃度易受CYP2C19基因多態(tài)性、性別、年齡、聯(lián)合用藥等多種因素影響，因此為提高療效、減少不良反應，進行治療藥物濃度監(jiān)測十分重要。就伏立康唑治療藥物濃度監(jiān)測的影響因素如個體差異大、CYP2C19基因多態(tài)性、藥物間相互作用多、年齡因素、其他因素等進行綜述，旨在為伏立康唑的臨床合理應用提供參考。

Voriconazole is an effective treatment for a variety of deep fungal infections, but its pharmacokinetics are complex, the treatment window is narrow, individual differences are large, and its blood concentration is easily affected by CYP2C19 gene polymorphism, gender, age, combination medication, and other factors influence. In order to improve the curative effect and reduce adverse reactions, the concentration monitoring of therapeutic drugs is very important. This article reviews the influencing factors of voriconazole therapeutic drugs, such as large individual differences, CYP2C19 gene polymorphism, multiple drug interactions, and age factors, aiming to provide reference for the reasonable clinical application of voriconazole.

R978.5

安徽醫(yī)科大學?？蒲谢痦椖浚?019xkj069）