目的 探討芪血顆粒聯(lián)合二維亞鐵顆粒治療小兒缺鐵性貧血的臨床療效。方法 回顧性分析2019年2月—2021年2月在天津市兒童醫(yī)院進(jìn)行治療的106例缺鐵性貧血患兒臨床資料，根據(jù)用藥差別將所有患者分為對(duì)照組和治療組，每組各53例。對(duì)照組口服二維亞鐵顆粒，5 g/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服芪血顆粒，2～7歲，1袋/次，2次/d；8歲以上，1袋/次，3次/d。兩組均治療28 d進(jìn)行效果比較。觀察兩組的臨床療效，比較兩組臨床癥狀改善時(shí)間、貧血指標(biāo)和鐵代謝指標(biāo)。結(jié)果 經(jīng)治療，治療組總有效率是98.11%，顯著高于對(duì)照組的83.02%（P<0.05）。經(jīng)治療，治療組皮膚和黏膜蒼白、食欲不振、精神不振、不愿活動(dòng)、頭暈改善時(shí)間均顯著短于對(duì)照組（P<0.05）。經(jīng)治療，兩組患兒血紅蛋白、紅細(xì)胞平均體積（MCV）、平均血紅蛋白量（MCH）、紅細(xì)胞平均血紅蛋白濃度（MCHC）水平均顯著增高（P<0.05）；且治療組貧血指標(biāo)改善優(yōu)于對(duì)照組（P<0.05）。經(jīng)治療，兩組患兒血清鐵蛋白（SF）、血清鐵（SI）均較治療前顯著升高，但轉(zhuǎn)鐵蛋白受體（sTFR）、總鐵結(jié)合力（TIBC）水平均顯著降低（P<0.05）；治療后，治療組鐵代謝指標(biāo)改善優(yōu)于對(duì)照組（P<0.05）。結(jié)論 芪血顆粒聯(lián)合二維亞鐵顆粒治療小兒缺鐵性貧血具有較好臨床療效，可有效改善患兒臨床癥狀和鐵代謝指標(biāo)，有著良好的臨床應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Qixue Granules combined with compound ferrous fumarate and Vitamin B in treatment of iron deficiency anemia in children. Methods Retrospective analysis was performed on the clinical data of 106 children with iron deficiency anemia treated in Tianjin Children's Hospital from February 2019 to February 2021. All children were divided into control group and treatment group according to medication difference, with 53 cases in each group. Children in the control group were po administered with Compound Ferrous Fumarate and Vitamin B Granules, 5 g/time, twice daily. Children in the treatment group were po administered with Qixue Granules on the basis of the control group, 2-7 years old, 1 bag/time, twice daily, more than age 8 years old, 1 bag/time, 3 times daily. Children in two groups were treated for 28 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, anemia index and iron metabolism index were compared between the two groups. Results After treatment, the total effective rate of treatment group was 98.11%, which was significantly higher than that of control group (83.02%) (P < 0.05). After treatment, the improvement time of skin and mucosa pallor, loss of appetite, indolence of spirit, unwillingness to activity, and dizziness in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of hemoglobin (Hb), mean RBC volume (MCV), mean hemoglobin volume (MCH), and mean RBC hemoglobin concentration (MCHC) in two groups were significantly increased (P < 0.05). After treatment, the improvement of anemia index in treatment group was better than that in control group (P < 0.05). After treatment, serum ferrin (SF) and serum iron (SI) in two groups were significantly increased compared with those before treatment, but the levels of transferrin receptor (sTFR) and total iron binding capacity (TIBC) were significantly decreased (P < 0.05). After treatment, the improvement of iron metabolism index in treatment group was better than that in control group (P < 0.05). Conclusion Qixue Granules combined with compound ferrous fumarate and Vitamin B has good clinical effect in treatment of iron deficiency anemia in children, and can effectively improve the clinical symptoms of children, promote the improvement of iron metabolism indicators, which has good clinical application value.

R985;R977

天津市科技計(jì)劃項(xiàng)目（18JCTPJC36430）