目的 觀察腎炎舒片聯(lián)合嗎替麥考酚酯片治療慢性腎炎的臨床療效。方法 選取2019年2月—2020年9月在駐馬店市中心醫(yī)院就診的105例慢性腎炎患者，根據(jù)患者病歷單雙號將其分為對照組（53例）和治療組（52）例。對照組口服嗎替麥考酚酯片，1 g/次，2次/d。治療組在對照組治療基礎上口服腎炎舒片，6片/次，3次/d。兩組患者治療8周。觀察兩組的臨床療效，比較兩組腎功能指標[24 h蛋白尿定量（24 h UPQ）、腎小球濾過率（eGFR）]、炎癥指標[白細胞介素-6（IL-6）、超敏C反應蛋白（hs-CRP）]和免疫指標[免疫球蛋白A（IgA）、補體C3]。結果 治療后，治療組的總有效率（94.23%）高于對照組（79.25%）（P<0.05）。治療后，兩組患者24 h UPQ水平低于治療前，eGFR水平高于治療前（P<0.05），且治療組24 h UPQ水平低于對照組，eGFR水平高于對照組（P<0.05）。治療后，兩組hs-CRP、IL-6、IgA水平均低于治療前，補體C3水平高于治療前（P<0.05），且治療組hs-CRP、IL-6、IgA水平低于對照組，補體C3水平高于對照組（P<0.05）。結論 腎炎舒片聯(lián)合嗎替麥考酚酯片治療慢性腎炎患較嗎替麥考酚酯單用療效好，更利于改善患者腎功能，抑制異常免疫反應，降低炎癥反應，安全性較好。

Objective To observe the clinical effect of Shenyanshu Tablets combined with Mycophenolate Mofetil Tablets in treatment of chronic nephritis. Methods Patients (105 cases) with chronic nephritis in Zhumadian Central Hospital from February 2019 to September 2020 were divided into the control group (53 cases) and the treatment group (52 cases) according to the patient's medical records. Patients in the control group were po administered with Mycophenolate Mofetil Tablets, 1 g/time, twice daily. Patients in the treatment group were po administered with Shenyanshu Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the renal function indexes (24 h UPQ and eGFR), inflammatory indexes (IL-6 and hs-CRP) and immune indexes (IgA and complement C3) in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.23%) was higher than that of the control group (79.25%) (P < 0.05). After treatment, the level of 24-h UPQ in two groups was lower than that before treatment, but the level of eGFR was higher than that before treatment (P < 0.05). After treatment, the level of 24-h UPQ in the treatment group was lower than that in the control group, but the level of eGFR was higher than that in the control group (P < 0.05). After treatment, the levels of hs-CRP, IL-6, and IgA in two groups were lower than those before treatment, but the level of complement C3 in two groups was higher than that before treatment (P < 0.05). The levels of hs-CRP, IL-6, and IgA in the treatment group were lower than those in the control group, but the level of complement C3 in the treatment group was higher than that in the control group (P < 0.05). Conclusion Shenyanshu Tablets combined with Mycophenolate Mofetil Tablets has better effect than mycophenolate mofetil alone in treatment of chronic nephritis, which is beneficial to improve renal function, inhibit abnormal immune reaction of patients, reduce inflammatory response, with good safety.

R983

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