氧化苦參堿具有抗腎缺血再灌注損傷、抗內(nèi)毒素性腎損傷、抗四氯化碳致慢性腎損傷、抗阿霉素腎病、抗輸尿管梗阻大鼠腎間質(zhì)纖維化和抗高糖、高脂誘導的腎臟纖維化的作用。氧化苦參堿腎臟保護作用的作用機制是抗氧化、抗炎、降血糖、調(diào)血脂作用，抑制活性氧（ROS）/TLR4、PERK/ATF4/CHOP、JAK2/STATs、TGF-β1/Smads和NF-κB/TNF-α信號通路，減輕腎損傷炎癥反應(yīng)和細胞外基質(zhì)沉積，阻滯腎損傷和纖維化。

Oxymatrine has antagonisms to kidney ischemia/reperfusion injury, endotoxic renal injury, CCl₄-inguced chronic renal injury, adriamycin nephrosis, renal interstitial fibrosis after ureteral obstruction in rat, and renal fibrosis induced by high glucose and high fat. Its mechanisms of renal protection are antioxidation, anti-inflammation, hypoglycemia, and hypolipemia of oxymatrine, and inhibiting signaling pathways of ROS/TLR4, PERK/ATF4/CHOP, JAK2/STATs, TGF-β1/Smads, and NF-κB/TNF-α, to alleviate renal tissue inflammation and extracellular matrix deposit, and block renal injury and fibrogenesis.

R983