目的 探討注射用利福霉素鈉聯(lián)合注射用美羅培南治療小兒化膿性腦膜炎療效。方法 回顧性分析2020年3月—2021年3月在南陽市中心醫(yī)院治療的96例化膿性腦膜炎患兒臨床資料，根據(jù)用藥的差別分為對照組和治療組，每組各48例。對照組靜脈滴注注射用美羅培南，每次20 mg/kg同生理鹽水100 mL配伍，每8 h 1次；治療組在對照組基礎(chǔ)上靜脈滴注注射用利福霉素鈉，每次15 mg/kg同生理鹽水100 mL配伍，12 h 1次每。兩組均經(jīng)10 d治療。觀察兩組患兒臨床療效，比較治療前后兩組患兒臨床癥狀改善時(shí)間，及血清乳酸（LACT）、降鈣素原（PCT）、硫化氫（H₂S）和一氧化氮（NO）水平。結(jié)果 經(jīng)治療，治療組總有效率顯著高于對照組（97.92%vs 83.33%，P<0.05）。經(jīng)治療，治療組臨床癥狀改善時(shí)間明顯早于對照組（P<0.05）。經(jīng)治療，兩組患者血清LACT、PCT、H₂S和NO水平明顯降低（P<0.05），且以治療組下降最顯著（P<0.05）。結(jié)論 注射用利福霉素鈉聯(lián)合注射用美羅培南治療小兒化膿性腦膜炎可有效改善患兒臨床癥狀，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the curative effect of rifamycin combined with meropenem in treatment of children with purulent meningitis. Methods The clinical data of 96 children with purulent meningitis treated in Nanyang Central Hospital from March 2020 to March 2021 were analyzed retrospectively, and divided into control and treatment groups according to the difference of medication, and each group had 48 cases. Children in the control group were iv administered with Meropenem for injection, 20 mg/kg added into normal saline 100 mL, once every 8 h. Children in the treatment group were iv administered with Rifamycin Sodium for injection, 15 mg/kg added into normal saline 100 mL, once every 12 h. Children in two groups were treated for 10 d. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, the levels of serum cytokine LACT, PCT, H₂S, and NO in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (97.92% vs 83.33%, P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the serum levels of LACT, PCT, H₂S, and NO in two groups were significantly decreased (P< 0.05), especially in the treatment group (P < 0.05). Conclusion Rifamycin combined with meropenem in treatment of children with purulent meningitis can effectively improve the clinical symptoms, which has a certain clinical application value. on the basis of the control group.

R985

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃聯(lián)合共建項(xiàng)目（LHGJ20191453）