2降低,6-酮-前列腺素F1α(6-keto-PGF1α)、一氧化氮(NO)升高(P<0.05),且治療后,治療組ET-1、血栓素B2低于對照組,6-keto-PGF1α、NO高于對照組(P<0.05)。結(jié)論 脈管復(fù)康片聯(lián)合西洛他唑片治療下肢動(dòng)脈硬化閉塞癥具有較好療效,可提高ABI,減輕下肢缺血癥狀,促進(jìn)局部血液循環(huán),改善血管內(nèi)皮功能,有一定的應(yīng)用價(jià)值。;Objective To observe the clinical efficacy of Maiguan Fukang Tablets combined with Cilostazol Tablets in treatment of lower extremity arteriosclerosis obliterans. Methods Patients (68 cases) with lower extremity arteriosclerosis obliterans in People's Hospital of Henan University of Chinese Medicine (People's Hospital of Zhengzhou) from April 2019 to December 2020 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were po administered with Cilostazol Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Maiguan Fukang Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and arteriosclerosis index, hemodynamic index, and vascular endothelial function index in two groups were compared. Results After treatment, the total effective rate in the treatment group was 88.24%, which was higher than 67.65% in the control group (P < 0.05). After treatment, the ABI in two groups were increased, but the vessel diameter expanded, peak flow rate in two groups were decreased, and the blood flow in two groups were increased (P< 0.05). After treatment, the peak flow rate in the treatment group was lower than that in the control group, and the ABI, blood flow, and vessel diameter in the treatment group were higher than those in the control group (P < 0.05). After treatment, the whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity, and cell sedimentation rate in two groups were decreased (P < 0.05), and the whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity, and cell sedimentation rate in the treatment group were lower than those in the control group (P < 0.05). After treatment, the ET-1 and thromboplug B2 in two groups were decreased, but the 6-keto-PGF1α and NO in two groups were increased (P < 0.05). After treatment, the ET-1 and thromboplug B2 in the treatment group were lower than those in the control group, and 6-keto-PGF1α and NO were higher than those in the control group (P < 0.05). Conclusion Maiguan Fukang Tablets combined with Cilostazol Tablets has clinical curative effect in treatment of lower extremity arteriosclerosis obliterans, can improve ABI, reduce the symptoms of lower limb ischemia, promote local blood circulation, and improve vascular endothelial function, which has a certain application value."/>

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首頁 > 過刊瀏覽>2021年第36卷第12期 >2021,36(12):2569-2573. DOI:10.7501/j.issn.1674-5515.2021.12.020
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脈管復(fù)康片聯(lián)合西洛他唑治療下肢動(dòng)脈硬化閉塞癥的臨床研究

Clinical study on Maiguan Fukang Tablets combined with cilostazol in treatment of lower extremity arteriosclerosis obliterans

發(fā)布日期:2021-12-22