中性粒細胞胞外陷阱是由中性粒細胞釋放到外周而發(fā)揮作用的一種復(fù)合物。人們在腦梗死患者的血栓中發(fā)現(xiàn)了中性粒細胞細胞外陷阱，并發(fā)現(xiàn)中性粒細胞細胞外陷阱與動脈粥樣硬化、血栓形成密切相關(guān)。中性粒細胞細胞外陷阱可以降低動脈粥樣硬化斑塊的穩(wěn)定性，促進血栓的形成，影響梗死后新生血管的生成，中性粒細胞細胞外陷阱還與溶栓后的出血相關(guān)，不同類型腦梗死中中性粒細胞細胞外陷阱的分布也存在差異，并且在中性粒細胞細胞外陷阱中發(fā)現(xiàn)了炎性小體相關(guān)成分，這些都表明中性粒細胞細胞外陷阱在腦梗死發(fā)病機制中發(fā)揮著重要作用。因此就中性粒細胞細胞外陷阱在腦梗死發(fā)病機制中的作用進行綜述，主要總結(jié)了中性粒細胞細胞外陷阱在動脈粥樣硬化、血栓形成、腦梗死后溶栓中的作用以及對腦梗死后新生血管、不同類型腦梗死以及通過炎性小體對腦梗死的影響。

Neutrophil extracellular traps (NETs) are complexes that are released by neutrophils into the periphery to function. NETs have been identified in thrombi from patients with cerebral infarction and have been found to be closely associated with atherosclerosis, thrombosis. NETs can reduce the stability of atherosclerotic plaques, promote thrombus formation, and affect post- infarction neovascularization. NETs have also been associated with bleeding after thrombolysis. The distribution of NETs varies in different types of cerebral infarction, and inflammatory vesicle-associated components were found. All these suggest that NETs play an important role in the pathogenesis of cerebral infarction. This article reviews the role of NETs in the pathogenesis of cerebral infarction. This paper mainly summarizes the role of neutrophil extracellular traps in atherosclerosis, thrombosis, and thrombolysis after cerebral infarction, as well as the effect on neovascularization after cerebral infarction, the effect on different types of cerebral infarction, different types of cerebral infarction, and the effect on cerebral infarction through inflammasome.

R971

天津市科技計劃項目（19ZXDBSY00100）；天津市第三中心醫(yī)院、天津市重癥疾病體外生命支持重點實驗室國家自然科學(xué)基金孵育項目（2019YNR5）