隨著人口老齡化，骨質(zhì)疏松的發(fā)病率顯著增加，嚴(yán)重影響患者的生活質(zhì)量。近年來，隨著表觀遺傳學(xué)的深入研究，非編碼RNA（包括長鏈非編碼RNA、微小RNA、環(huán)狀RNA）成為研究熱點(diǎn)，已發(fā)現(xiàn)其可參與多種疾病的調(diào)節(jié)。越來越多的證據(jù)表明非編碼RNA在骨代謝過程中發(fā)揮重要的調(diào)節(jié)作用，具有作為骨質(zhì)疏松的診斷生物標(biāo)志物和治療靶標(biāo)的巨大潛力。因此對骨質(zhì)疏松相關(guān)的非編碼RNA的研究進(jìn)展進(jìn)行綜述。

With the aging of the population, the incidence of osteoporosis has increased significantly, which seriously affects the quality of life of patients. In recent years, with the in-depth study of epigenetics, non-coding RNAs (including long non-coding RNAs, microRNAs, and circRNAs) have become a research hotspot, and they have been found to be involved in the regulation of a variety of diseases. More and more evidences show that non-coding RNA plays an important regulatory role in bone metabolism and has great potential as a diagnostic biomarker and therapeutic target for osteoporosis. In this article, the research progress of osteoporosis related non-coding RNA is reviewed.

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