目的 探討保和口服液聯(lián)合西沙必利治療小兒功能性消化不良的臨床研究。方法 選取2019年2月—2021年2月在鄭州大學(xué)附屬兒童醫(yī)院診治的138例小兒功能性消化不良患兒，根據(jù)隨機(jī)數(shù)字表法分為對照組和治療組，每組各69例。對照組口服西沙必利混懸液，稀釋成1 mg/mL，0.2 mg/kg，2次/d。治療組患兒在對照組基礎(chǔ)上口服保和口服液，10 mL/次，2次/d。兩組患兒連續(xù)治療7 d。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀緩解時(shí)間，血漿胃泌素（GAS）、胃動(dòng)素（MTL）、5-羥色胺（5-HT）和一氧化氮（NO）水平，血清炎性因子白細(xì)胞介素-10（IL-10）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）和干擾素-γ（IFN-γ）水平及不良反應(yīng)。結(jié)果 治療后，治療組患兒總有效率為98.55%，明顯高于對照組的85.51%（P＜0.05）。治療后，治療組患兒臨床癥狀惡心嘔吐、腹脹、腹痛、厭食緩解時(shí)間均早于對照組（P＜0.05）。治療后，兩組患兒GAS、MTL水平明顯升高，而5-HT和NO水平明顯降低（P＜0.05），且治療組患兒GAS、MTL、5-HT、NO水平明顯好于對照組（P＜0.05）。治療后，兩組血清炎性因子IL-10水平明顯升高，而IL-6、TNF-α和IFN-γ水平明顯降低（P＜0.05），且治療組患兒血清炎性因子水平明顯好于對照組（P＜0.05）。治療組患兒不良反應(yīng)發(fā)生率明顯低于對照組（P＜0.05）。結(jié)論 保和口服液與西沙必利聯(lián)合治療小兒功能性消化不良療效明顯，臨床癥狀緩解快，能改善胃腸激素水平，降低炎性反應(yīng)，藥物不良反應(yīng)小。

Objective To investigate the curative effect of Baohe Oral Liquid combined with cisapride in treatment of children with functional dyspepsia.Methods Children (138 cases) with functional dyspepsia in Children's Hospital Affiliated to Zhengzhou University from February 2019 to February 2021 were divided into control and treatment group according to random number table method, and each group had 69 cases. Children in the control group were po administered with Cisapride Suspension, which was diluted to 1 mg/mL, 0.2 mg/kg, twice daily. Children in the treatment group were po administered with Baohe Oral Liquid on the basis of the control group, 10 mL/time, twice daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the relief time of clinical symptom, the levels of GAS, MTL, 5-HT, and NO, the levels of serum inflammatory factors, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was 98.55%, which was significantly higher than that of the control group (85.51%) (P < 0.05). After treatment, the relief time of nausea and vomiting, abdominal distension, abdominal pain and anorexia in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the levels of GAS and MTL in two groups were significantly increased, while the levels of 5-HT and NO were significantly decreased, and the levels of GAS, MTL, 5-HT, and NO in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the level of serum inflammatory factors IL-10 was significantly increased, while the levels of IL-6, TNF-α, and IFN-γ were significantly decreased in two groups, and the level of serum inflammatory factors in the treatment group was significantly better than that in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P < 0.05).Conclusion The curative effect of Baohe Oral Liquid combined with cisapride in treatment of children with functional dyspepsia is obvious, which can quickly relieve the clinical symptoms, improve the level of gastrointestinal hormone, reduce the inflammatory reaction, and the adverse drug reaction is small.

R975

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃省部共建項(xiàng)目（SBGJ202002125）