目的 探究新膚螨靈軟膏聯(lián)合異維A酸紅霉素凝膠治療尋常型痤瘡的臨床療效。方法 選取2019年5月—2021年5月南陽市中心醫(yī)院收治的106例尋常型痤瘡患者為研究對象，采用隨機數(shù)字表法將所有患者分為對照組和治療組，每組各53例。對照組取適量異維A酸紅霉素凝膠涂抹于患處，1次/d。治療組在對照組基礎上取適量新膚螨靈軟膏涂抹于面部，每日早上、睡眠各1次。兩組患者連續(xù)治療4周。觀察兩組的臨床療效，并比較治療前后臨床癥狀評分、皮脂分泌率（SER）、炎癥因子水平。結果 治療后，治療組患者的總有效率（92.45%）明顯高于對照組（83.02%），組間比較差異具有統(tǒng)計學意義（P＜0.05）。治療后，兩組紅斑評分、色素沉著評分、銀屑病皮損面積和嚴重程度指數(shù)（PASI）評分均顯著降低（P＜0.05），并且治療后治療組紅斑評分、色素沉著評分、PASI評分均明顯低于對照組（P＜0.05）。治療后，兩組SER均降低（P＜0.05），且治療組SER低于對照組（P＜0.05）。治療后，兩組患者血清腫瘤壞死因子-α（TNF-α）、白細胞介素-1β（IL-1β）、白細胞介素-6（IL-6）水平均顯著降低（P＜0.05），并且治療組血清TNF-α、IL-1β、IL-6水平均低于對照組（P＜0.05）。結論 新膚螨靈軟膏聯(lián)合異維A酸紅霉素凝膠可有效改善尋常型痤瘡患者紅斑、色素沉著，減輕機體炎癥反應，有一定的臨床推廣應用價值。

Objective To explore the efficacy of Xinfu Manling Ointment combined with Isotretinoin Erythromycin Gel in treatment of acne vulgaris.Methods Patients (106 cases) with acne vulgaris in Nanyang Central Hospital from May 2019 to May 2021 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were given appropriate amount of Isotretinoin Erythromycin Gel, once daily. Patients in the treatment group were appropriate amount of Xinfu Manling Ointment on the basis of the control group, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the clinical symptom score, the sebum secretion rate (SER), and the levels of inflammatory factors in two groups were compared.Results After treatment, the total effective rate of the treatment group (92.45%) was significantly higher than that of the control group (83.02%), and the difference was statistically significant (P < 0.05). After treatment, the erythema score, pigmentation score, and PASI score of two groups were significantly decreased (P < 0.05), and the erythema score, pigmentation score, and PASI score in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the SER in two groups were significantly decreased (P < 0.05), and the SER in the treatment group was lower than that in the control group (P < 0.05). After treatment, the serum levels of TNF-α, IL-1β, and IL-6 in two groups were significantly decreased (P < 0.05), and the serum levels of TNF-α, IL-1β, and IL-6 in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion Xinfu Manling Ointment combined with Isotretinoin Erythromycin Gel can effectively improve the erythema and pigmentation of patients with acne vulgaris, reduce the body's inflammatory reaction, which has a certain clinical application value.

R986

河南省醫(yī)學科技攻關計劃共建項目（SB201904011）