目的 探討舒血寧注射液聯(lián)合乙哌立松治療椎動(dòng)脈型頸椎病的臨床效果。方法 選取2019年4月—2020年11月河南科技大學(xué)第一附屬醫(yī)院開元院區(qū)收治的166例椎動(dòng)脈型頸椎病患者，以隨機(jī)數(shù)字表法分成對(duì)照組（83例）和治療組（83例）。對(duì)照組口服鹽酸乙哌立松片，1片/次，3次/d。在對(duì)照組基礎(chǔ)上，治療組靜脈滴注舒血寧注射液，20 mL加入5%葡萄糖注射液250 mL，1次/d。兩組連續(xù)治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者眩暈殘障程度評(píng)定量表（DHI）、頸椎功能障礙指數(shù)（NDI）和椎動(dòng)脈型頸椎病功能評(píng)定量表（FS-CSA）評(píng)分，基底動(dòng)脈（BA）、左椎動(dòng)脈（LVA）和右椎動(dòng)脈（RVA）的平均血流速度，血清腫瘤壞死因子-α（TNF-α）、內(nèi)皮素-1（ET-1）、一氧化氮（NO）水平。結(jié)果 治療后，治療組總有效率為96.4%，較對(duì)照組的84.3%顯著升高（P＜0.05）。治療后，兩組患者DHI、NDI和FS-CSA評(píng)分均顯著下降（P＜0.05），且治療組降低更顯著（P＜0.05）。治療后，兩組BA、LVA和RVA的平均血流速度均顯著增加（P＜0.05），且治療組增加更顯著（P＜0.05）。治療后，兩組血清TNF-α、ET-1水平顯著下降，而血清NO水平則顯著上升（P＜0.05），且治療組血清TNF-α、ET-1和NO水平明顯好于對(duì)照組（P＜0.05）。結(jié)論 舒血寧注射液聯(lián)合乙哌立松治療椎動(dòng)脈型頸椎病療效確切，可安全有效地減輕患者眩暈等癥狀，改善椎動(dòng)脈血流動(dòng)力學(xué)，糾正血管內(nèi)皮功能紊亂，提高患者生活質(zhì)量。

Objective To investigate the clinical effect of Shuxuening Injection combined with eperisone in treatment of cervical spondylosis of vertebral artery type.Methods Patients (166 cases) with cervical spondylosis of vertebral artery type in Kaiyuan Branch, First Affiliated Hospital of Henan University of Science and Technology from April 2019 to November 2020 were divided into control (83 cases) and treatment (83 cases) group by random number table method. Patients in the control group were po administered with Eperisone Hydrochloride Tablets, 1 tablet/time, three times daily. Patients in the treatment group were iv administered with Shuxuening Injection on the basis of the control group, 20 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, the scores of DHI, NDI and FS-CSA, the vertebral artery hemodynamic parameters, the levels of serum TNF-α, ET-1 and NO in two groups before and after treatment were compared.Results After treatment, the total effective rate of the treatment group was 96.4%, which was significantly higher than that of the control group (84.3%) (P < 0.05). After treatment, the scores of DHI, NDI and FS-CSA in two groups were significantly decreased (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the mean blood flow velocity of BA, LVA and RVA in two groups were significantly increased (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the levels of serum TNF- α and ET-1 were significantly decreased, while the level of serum NO were significantly increased in two groups, (P < 0.05) and the levels of TNF-α, ET-1, and NO in the treatment group were significantly better than those in the control group (P < 0.05).Conclusion Shuxuening Injection combined with eperisone is effective in treatment of cervical spondylosis of vertebral artery type, which can safely and effectively reduce symptoms such as vertigo, improve vertebral artery hemodynamics and correct vascular endothelial dysfunction, and improve the life quality of patients.

R971