目的 探討強(qiáng)力枇杷膠囊聯(lián)合沙丁胺醇治療慢性喘息性支氣管炎急性發(fā)作的臨床療效。方法 選取2019年9月—2021年9月南陽市第二人民醫(yī)院收治的80例慢性喘息性支氣管炎急性發(fā)作患者，按照隨機(jī)數(shù)字表法將所有患者隨機(jī)分為對(duì)照組和治療組，每組各40例。對(duì)照組霧化吸入吸入用硫酸沙丁胺醇溶液，用生理鹽水將0.5 mL本品稀釋至2 mL，將2 mL藥液置于噴霧器中，讓患者吸入霧化的溶液，直至氣霧停止產(chǎn)生，2次/d。治療組患者在對(duì)照組治療基礎(chǔ)上口服強(qiáng)力枇杷膠囊，2粒/次，3次/d。兩組連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組臨床癥狀好轉(zhuǎn)時(shí)間、血清因子水平。結(jié)果 治療后，治療組總有效率是97.50%，顯著高于對(duì)照組的77.50%（P<0.05）。治療后，治療組患者發(fā)熱、咳嗽、咳痰、胸悶臨床癥狀好轉(zhuǎn)時(shí)間均顯著短于對(duì)照組（P<0.05）。治療后，兩組白細(xì)胞介素6（IL-6）、白細(xì)胞介素8（IL-8）、內(nèi)皮素（ET-1）、腫瘤壞死因子-α（TNF-α）水平均較治療前顯著降低（P<0.05），治療后，治療組血清因子水平顯著低于對(duì)照組（P<0.05）。結(jié)論 強(qiáng)力枇杷膠囊聯(lián)合沙丁胺醇溶液治療慢性喘息性支氣管炎急性發(fā)作具有較好的臨床療效，可使患者癥狀顯著好轉(zhuǎn)，并能有效降低支氣管炎性反應(yīng)，值得臨床借鑒與推廣。

Objective To explore the clinical study of Qiangli Pipa Capsules combined with salbutamol in treatment of acute attack of chronic asthmatic bronchitis. Methods A total of 80 patients with acute attack of chronic asthmatic bronchitis admitted to Nanyang Second People's Hospital from September 2019 to September 2021 were selected, and all patients were randomly divided into control group and treatment group according to random number table, with 40 cases in each group. Patients in the control group were inhaled with Salbutamol Sulfate Solution for Inhalation, diluted 0.5 mL to 2 mL with normal saline, placed 2 mL of the solution in a nebulizer and let client inhale the atomized solution until the aerosol stops producing, twice daily. Patients in the treatment group were po administered with Qiangli Pipa Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and clinical symptom improvement time and serum factor level were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 97.50%, significantly higher than that of the control group (77.50%) (P < 0.05). After treatment, the improvement time of clinical symptoms of fever, cough, expectoration, and chest tightness in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the levels of interleukin-6 (IL-6), interleukin-8 (IL-8), endothelin (ET-1), and tumor necrosis factor -α (TNF-α) in two groups were significantly decreased compared with before treatment (P < 0.05), and the serum factor levels in treatment group were significantly lower than that in control group (P < 0.05). Conclusion Qiangli Pipa Capsules combined with salbutamol has good clinical effect in treatment of acute attack of chronic asthmatic bronchitis, and can significantly improve the symptoms of patients and effectively reduce bronchial inflammatory reaction, which is worthy of clinical reference and promotion.

R974

河南省醫(yī)學(xué)科技攻關(guān)聯(lián)合共建項(xiàng)目（LHGJ20191465）