目的 探討金天格膠囊聯(lián)合地奧司明片治療腰椎間盤突出癥的臨床療效。方法 選取2020年2月—2021年7月鄭州市骨科醫(yī)院收治的104例腰椎間盤突出癥患者，按照隨機數(shù)字表法將所有患者分為對照組和治療組，每組各52例。對照組口服地奧司明片，0.45 g/次，2次/d。治療組在對照組治療的基礎上溫水送服金天格膠囊，1.2 g/次，3次/d。兩組患者共連續(xù)治療3個月后統(tǒng)計療效。觀察兩組的臨床療效，比較兩組疼痛程度、腰椎功能和血清中前列腺素E₂（PGE₂）、神經(jīng)肽（NPY）、5-羥色胺（5-HT）水平。結果 治療后，治療組總有效率為94.23%，明顯高于對照組的80.77%，差異有統(tǒng)計學意義（P<0.05）。治療1、3個月后，兩組VAS評分均顯著降低（P<0.05），且治療組比對照組同期VAS評分減輕更明顯，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組的日本骨科協(xié)會腰椎功能量表（JOA）評分均顯著提高（P<0.05）；且治療組的JOA評分改善程度比對照組高（P<0.05）。治療后，兩組的PGE₂、NPY、5-HT水平均顯著下降（P<0.05）；且治療組的PGE₂、NPY、5-HT水平低于對照組，差異有統(tǒng)計學意義（P<0.05）。結論 金天格膠囊聯(lián)合地奧司明片治療腰椎間盤突出癥具有較好的臨床療效，可改善腰椎功能，降低患者疼痛程度，調節(jié)PGE₂、NPY、5-HT水平，安全性較好。

Objective To investigate the effect of Jintiange Capsules combined with Diosmin Tablets in treatment of lumbar disc herniation. Methods Patients (104 cases) with cerebral infarction in Zhengzhou Orthopedic Hospital from February 2020 to July 2021 were randomly divided into control and treatment groups, and each group had 52 cases. Patients in the control group were po administered with Diosmin Tablets, 0.45 mg/time, twice daily. Patients in the treatment group were po administered with Jintiange Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and pain degree, lumbar function, and the levels of PGE₂, NPY, and 5-HT in two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.23%, which was significantly higher than that of the control group (80.77%), with significant difference (P< 0.05). After 1 and 3 months of treatment, the VAS scores of two groups were significantly decreased (P < 0.05), and the VAS score of the treatment group was significantly lower than that of the control group at the same time (P < 0.05). After treatment, the JOA scores of two groups were significantly increased (P < 0.05), and the improvement of JOA score in the treatment group was higher than that in the control group (P < 0.05). After treatment, the levels of PGE₂, NPY, and 5-HT in two groups were significantly decreased (P< 0.05), and the levels of PGE₂, NPY, and 5-HT in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Jintiange Capsules combined with Diosmin Tablets has clinical curative effect in treatment of lumbar disc herniation, can improve lumbar function, reduce the degree of pain, and adjust the levels of PGE₂, NPY, and 5-HT, with good safety.

R977

河南省醫(yī)學科技攻關計劃（聯(lián)合共建）項目（LHGJ20191139）