目的 探討丹紅注射液聯(lián)合乙酰谷酰胺注射液治療急性腦梗死恢復(fù)期的臨床療效。方法 選取2020年1月—2021年8月在濮陽市人民醫(yī)院確診并治療的136例腦梗死恢復(fù)期患者，按照隨機(jī)數(shù)字表法，將患者分為對(duì)照組和治療組，每組各68例。對(duì)照組患者靜脈滴注乙酰谷酰胺注射液，0.6 g加入5%葡萄糖注射液250 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注丹紅注射液，40 mL加入5%葡萄糖注射液250 mL中，1次/d。兩組患者均連續(xù)治療2周。觀察兩組患者的臨床療效，比較兩組治療前后相關(guān)評(píng)分、頸總動(dòng)脈和大腦中動(dòng)脈血流動(dòng)力學(xué)指標(biāo)、氧化應(yīng)激指標(biāo)和血管新生促進(jìn)因子指標(biāo)的變化情況。結(jié)果 治療后，治療組總有效率為95.59%，顯著高于對(duì)照組的86.76%（P<0.05）。治療后，兩組患者的NIHSS評(píng)分、mRS評(píng)分均較治療前有顯著下降，而FMA評(píng)分均明顯上升（P<0.05），且治療后，治療組患者NIHSS、FMA、mRS評(píng)分改善優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者頸總動(dòng)脈、大腦中動(dòng)脈收縮期峰值血流速度（PSV）、舒張期末血流速度（EDV）水平均較治療前顯著提高，但搏動(dòng)指數(shù)（PI）均顯著下降（P<0.05），且治療后，治療組患者血流動(dòng)力學(xué)參數(shù)水平改善優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者谷胱甘肽過氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）水平均較治療前顯著提高，8-OHdG8-羥基脫氧鳥苷（8-OHdG）、氧化型低密度脂蛋白（ox-LDL）水平均顯著下降（P<0.05），且治療后，治療組患者氧化應(yīng)激水平改善優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者血管內(nèi)皮細(xì)胞生長因子（VEGF）、堿性成纖維細(xì)胞生長因子（bFGF）、轉(zhuǎn)化生長因子β1（TGF-β1）水平較治療前均顯著提高（P<0.05），且治療后治療組患者血管新生促進(jìn)因子指標(biāo)改善更明顯（P<0.05）。結(jié)論 丹紅注射液聯(lián)合乙酰谷酰胺注射液可治療急性腦梗死具有良好的臨床療效，可改善患者的神經(jīng)功能缺損程度，提高運(yùn)動(dòng)功能，調(diào)控氧化應(yīng)激反應(yīng)，促進(jìn)血管新生，值得臨床廣泛應(yīng)用。

Objective To investigate the clinical effect of Danhong Injection combined with Aceglutamide Injection in treatment of acute cerebral infarction convalescence. Methods A total of 136 convalescence patients with cerebral infarction diagnosed and treated in Puyang People's Hospital from January 2020 to August 2021 were selected and divided into control group and treatment group according to random number method, with 68 cases in each group. Patients in the control group were iv administered with Aceglutamide Injection, 0.6 g was added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were iv administered with Danhong Injection on the basis of the control group, 40 mL was added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of correlation scores, blood flow dynamics indexes, oxidative stress indexes and angiogenesis promoting factor indexes of common carotid artery and middle cerebral artery were compared before and after treatment. Results After treatment, the total effective rate in the treatment group was 95.59%, significantly higher than 86.76% in the control group (P < 0.05). After treatment, NIHSS and mRS scores in two groups were significantly decreased compared with before treatment, while FMA scores were significantly increased (P < 0.05), and NIHSS, FMA and mRS scores in the treatment group were improved better than those in the control group (P < 0.05). After treatment, two groups of patients with carotid artery, middle cerebral artery peak systolic velocity (PSV), final diastolic blood flow velocity (EDV) level was significantly increased, the but pulsation index (PI) were significantly decreased (P< 0.05), and after treatment, the treatment group patients hemodynamic parameters level improvement is better than that of control group (P< 0.05). After treatment, the levels of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) in two groups were significantly increased compared with before treatment, but the levels of 8-OHdG and oxidized low-density lipoprotein (ox-LDL) were significantly decreased (P < 0.05). The improvement of oxidative stress level in treatment group was better than that in control group (P < 0.05). After treatment, the levels of vascular endothelial cell growth factor (VEGF), basic fibroblast growth factor (bFGF) and transforming growth factor β1 (TGF-β1) in two groups were significantly increased compared with before treatment (P < 0.05), and the improvement of angiogenesis promoting factor indexes in treatment group was more obvious (P < 0.05). Conclusions Danhong Injection combined with Aceglutamide Injection has good clinical effect in treatment of acute cerebral infarction convalescence, and can improve the degree of neurological impairment, improve motor function, regulate oxidative stress response and promote angiogenesis, which is worthy of widespread clinical application.

R971