目的 探討康樂鼻炎片聯(lián)合鹽酸西替利嗪治療過敏性鼻炎的臨床效果。方法 選取2019年5月—2020年5月天津醫(yī)科大學(xué)中新生態(tài)城醫(yī)院收治的86例過敏性鼻炎患者，隨機(jī)分成對(duì)照組和治療組，每組各43例。對(duì)照組晚餐時(shí)口服鹽酸西替利嗪片，1片/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服康樂鼻炎片，4片/次，3次/d。兩組均連續(xù)治療4周。觀察兩組患者臨床療效，比較治療前后兩組患者典型表現(xiàn)評(píng)分，鼻結(jié)膜炎生活質(zhì)量調(diào)查問卷（RQLQ）總分，鼻功能指標(biāo)總鼻氣道阻力（NAR）、0~5 cm鼻腔容積（NCV）和鼻腔最小橫截面積（NMCA），及血清白細(xì)胞介素-5（IL-5）、IL-16、可溶性E-選擇素（sE-selectin）和嗜酸粒細(xì)胞趨化因子（Eotaxin）水平。結(jié)果 治療后，治療組臨床有效率為95.35%，顯著高于對(duì)照組的79.07%（P<0.05）。治療后，兩組噴嚏、流涕、鼻塞、鼻癢評(píng)分及總分均顯著低于治療前（P<0.05），且以治療組下降更顯著（P<0.05）。治療后，兩組RQLQ總分和NAR總分較同組治療前均顯著下降，而0~5 cm NCV和NMCA均顯著增大（P<0.05），且均以治療組的改善更顯著（P<0.05）。治療后，兩組血清IL-5、IL-16、sE-selectin和Eotaxin水平均顯著低于本組治療前（P<0.05），且治療組明顯低于對(duì)照組（P<0.05）。結(jié)論 康樂鼻炎片聯(lián)合鹽酸西替利嗪治療過敏性鼻炎的總體療效確切，是減輕患者鼻部癥狀、改善鼻腔通氣功能及提高生活質(zhì)量的安全有效途徑。

Objective To investigate the clinical effect of Kangle Biyan Tablets combined with cetirizine in treatment of allergic rhinitis. Methods Patients (86 cases) with allergic rhinitis in Sino-Singapore Eco-city Hospital of Tianjin Medical University from May 2019 to May 2020 were randomly divided into control and treatment group, and each group had 43 cases. Patients in the control group were po administered with Cetirizine Hydrochloride Tablets after dinner, 1 tablet/time, once daily. Patients the treatment group were po administered with Kangle Biyan Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, the typical performance scores, RQLQ total scores, nasal function indicators NAR, 0-5 cm NCV and NMCA, and the levels of serum IL-5, IL-16, sE-selectin and Eotaxin in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 95.35%, which was significantly higher than that of the control group (79.07%) (P< 0.05). After treatment, the scores of sneezing, runny nose, stuffy nose and nasal itching, and total scores in two groups were significantly lower than those before treatment (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the total score of RQLQ and total NAR in two groups were significantly lower than those in the same group before treatment, while 0-5 cm NCV and NMCA were significantly increased (P < 0.05), and the improvement in the treatment group was more significant than those in the treatment group (P< 0.05). After treatment, the serum concentrations of IL-5, IL-16, sE-selectin and Eotaxin in two groups were significantly lower than those before treatment (P < 0.05), of Kangle Biyan Tablets combined with cetirizine in treatment of allergic rhinitis is definite, which is a safe and effective method to relieve nasal symptoms, improve nasal ventilation function and quality of life.

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