目的 探討2017—2020年西安市中醫(yī)醫(yī)院常見革蘭陰性桿菌耐藥率與抗菌藥物使用強度（AUD）間的相關(guān)性，為抗菌藥物臨床應(yīng)用管理和合理用藥提供參考。方法 回顧性統(tǒng)計2017—2020年西安市中醫(yī)醫(yī)院大腸埃希菌、肺炎克雷伯菌、銅綠假單胞菌分離率、耐藥率以及住院患者AUD，應(yīng)用Spearman相關(guān)法對AUD與革蘭陰性桿菌耐藥率進(jìn)行相關(guān)性分析。結(jié)果 大腸埃希菌、肺炎克雷伯菌、銅綠假單胞菌占總分離菌株的58.62%。第3代頭孢菌素、喹諾酮類藥物AUD持續(xù)排名前2位。大腸埃希菌對阿米卡星耐藥率與對應(yīng)AUD呈極強負(fù)相關(guān)，對頭孢呋辛、頭孢噻肟耐藥率與對應(yīng)AUD呈極強正相關(guān)。結(jié)論 細(xì)菌耐藥率與AUD存在相關(guān)性，醫(yī)院應(yīng)注重細(xì)菌耐藥與抗菌藥物用量監(jiān)測，持續(xù)加強抗菌藥物管理，多方協(xié)作遏制細(xì)菌耐藥。

Objective To investigate the correlation between drug resistance rates of gram-negative bacilli and AUD in Xi'an Hospital of Traditional Chinese Medicine from 2017 to 2020, and to provide reference for clinical application management and rational drug use of antibiotics. Methods The isolation rate and drug resistance rate of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and AUD of inpatients in Xi'an Hospital of Traditional Chinese Medicine from 2017 to 2020 were retrospectively analyzed. Spearman correlation method was used to analyze the correlation between AUD and the drug resistance rate of gram-negative bacteria. Results Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa accounted for 58.62% of the total isolates. The third generation cephalosporins and quinolones' AUD continuously ranked the top two. The drug resistance rate of Escherichia coli to amikacin was strongly negatively correlated with corresponding AUD, while the drug resistance rate to cefuroxime and cefotaxime was strongly positively correlated with corresponding AUD. Conclusion Bacterial drug resistance rate is correlated with AUD. Hospital should pay attention to monitor the bacterial drug resistant and antibacterial consumption, and continue to strengthen the supervision of antibacterial. Through cooperation with different departments to curb bacterial drug resistant together.

R978.1

陜西省公共衛(wèi)生發(fā)展資助項目（陜中醫(yī)藥發(fā)【2021】2號）