腎素-血管緊張素-醛固酮系統(tǒng)（RAAS）是參與高血壓發(fā)病和維持不可或缺的環(huán)節(jié)；RAAS抑制劑治療高血壓被臨床廣泛應(yīng)用，其中主要包括直接腎素抑制劑、血管緊張素轉(zhuǎn)換酶抑制劑和血管緊張素受體拮抗劑。它們作用于RAAS不同靶點(diǎn)，對RAAS抑制劑有效性的影響及其臨床應(yīng)用地位和意義一直被人們所關(guān)注，因此對三者各靶點(diǎn)作用特點(diǎn)的進(jìn)行總結(jié)，以揭示RAAS抑制劑多靶點(diǎn)干預(yù)的重要性和意義。

Renin-angiotensin-aldosterone system (RAAS) is an indispensable link in the pathogenesis and maintenance of hypertension. RAAS inhibitors, mainly including direct renin inhibitors, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, are widely used in the treatment of hypertension. They act on different targets of RAAS, and their impact on the effectiveness of RAAS inhibition and their clinical application status and significance have been of interest. This article summarizes the characteristics of the three targets, to reveal the importance and significance of the intervention of different RAAS targets.

R977