目的 探討胃力膠囊聯(lián)合艾司奧美拉唑鎂治療膽汁反流性胃炎的臨床療效。方法 收集2020年4月-2020年12月洛陽市中醫(yī)院門診收治的92例膽汁反流性胃炎患者,所有患者按照隨機分組法分為對照組和治療組,每組各46例。對照組口服艾司奧美拉唑鎂腸溶片,20 mg/次,1次/d。治療組在對照組治療基礎上飯前口服胃力膠囊,4粒/次,1次/d。兩組觀察連續(xù)用藥7d。觀察兩組的臨床療效及癥狀緩解情況,比較兩組內(nèi)鏡分級積分、胃動素(MTL)、胃蛋白酶原I(PGI)、胃泌素(GAS)、胃蛋白酶原Ⅱ(PGII)。結果 治療后,治療組總有效率是97.82%,顯著高于對照組的80.43%(P<0.05)。治療組出現(xiàn)上腹燒灼感、胸骨后痛、腹部飽脹、膽汁性嘔吐緩解時間均顯著短于對照組(P<0.05)。治療后,兩組內(nèi)鏡分級積分較治療前均顯著降低(P<0.05);且治療后,治療組內(nèi)鏡分級積分低于對照組(P<0.05)。治療后,兩組血清MTL顯著升高,而PGI、GAS、PGII水平均較治療前顯著降低(P<0.05);治療后,治療組血清因子水平改善優(yōu)于對照組(P<0.05)。結論 艾司奧美拉唑鎂腸溶片與胃力膠囊聯(lián)合治療效果顯著,能改善患者內(nèi)鏡下的積分情況,有效促進胃部動力的恢復,值得臨床借鑒。

Objective To investigate Weili Capsules combined with esomeprazole magnesium in treatment of bile reflux gastritis. Methods A total of 92 patients with bile reflux gastritis admitted to the outpatient department of Luoyang Hospital of Traditional Chinese Medicine from April 2020 to December 2020 were collected. All patients were randomly divided into control group and treatment group, with 46 cases in each group. Patients in the control group were po administered with Esomeprazole Magnesium Enteric-coated Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Weili Capsules on the basis of the control group, 4 grains/time, once daily. The two groups were treated for 7 d. The clinical efficacy and symptom relief time of the two groups were observed, and the endoscopic grading score, MTL, pepsinogen I (PGI), gastrin (GAS), and pepsinogen II (PGII) of the two groups were compared. Results After treatment, the total effective rate of treatment group was 97.82%, significantly higher than that of control group 80.43% (P < 0.05). The relief time of epigastric burning, retrosternal pain, abdominal fullness, and bile vomiting in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the endoscopic grading score in both groups was significantly lower than that before treatment (P < 0.05). After treatment, the endoscopic grading score of the treatment group was lower than that of the control group (P < 0.05). After treatment, serum MTL was significantly increased, while the levels of PGI, GAS, and PGII were significantly decreased in both groups compared with before treatment (P < 0.05). After treatment, the level of serum factors in the treatment group was better than that in the control group (P < 0.05). Conclusion Weili Capsules combined with esomeprazole magnesium has remarkable effect in treatment of bile reflux gastritis, and can improve the score of patients under the endoscope, effectively promote the recovery of gastric motility, which is worthy of clinical reference.

R975

河南省醫(yī)學科技攻關計劃項目（2018020280）