[關(guān)鍵詞]
[摘要]
目的 探討參芪扶正注射液聯(lián)合氫化可的松注射液治療膿毒癥的臨床療效。方法 選取2019年8月-2021年9月在漯河市中心醫(yī)院就診的90例膿毒癥患者,按照隨機(jī)數(shù)字表法將90例患者分為對照組和治療組,每組各45例。對照組持續(xù)泵入氫化可的松注射液,100 mg/次,1次/8 h。治療組在對照組基礎(chǔ)上靜脈滴注參芪扶正注射液,250 mL/次,1次/d。兩組在治療7 d后統(tǒng)計療效。觀察兩組的臨床療效,比較兩組的急性生理學(xué)及慢性健康狀況評分系統(tǒng)(APACHE Ⅱ)評分、復(fù)蘇情況以及血清中C反應(yīng)蛋白(CRP)、白細(xì)胞介素-18(IL-18)、基質(zhì)金屬蛋白酶-1(ESM-1水平。結(jié)果 治療后,治療組的總有效率(88.89%)明顯高于對照組(71.11%)(P<0.05)。治療后,兩組的APACHE Ⅱ評分較治療前顯著降低(P<0.05),且治療組APACHE Ⅱ評分明顯低于對照組(P<0.05)。治療后,治療組的液體復(fù)蘇劑量、退熱時間、血壓恢復(fù)時間、完成復(fù)蘇時間均低于對照組,差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組的血清CRP、IL-18、ESM-1水平顯著減低(P<0.05);治療組的血清CRP、IL-18、ESM-1水平比對照組低(P<0.05)。結(jié)論 參芪扶正注射液聯(lián)合氫化可的松注射液能提高膿毒癥的療效,控制病情發(fā)展,促使患者復(fù)蘇,降低炎癥反應(yīng),治療安全性良好。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Shenqi Fuzheng Injection combined with Hydrocortisone Injection in treatment of sepsis. Methods Patients (90 cases) with sepsis in Luohe Central Hospital from August 2019 to September 2021 were divided into control and treatment groups according to the random number table method, and each group had 45 cases. Patients in the control group were continuous pumping administered with Hydrocortisone Injection, 100 mg/time, once every 8 h. Patients in the treatment group were iv administered with Shenqi Fuzheng Injection on the basis of the control group, 250 mL/time, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the APACHE Ⅱ score, resuscitation, and the serum levels of CRP, IL-18, and ESM-1 in two groups were compared. Results After treatment, the total efficacies of the treatment group (88.89%) was significantly higher than that of the control group (71.11%) (P < 0.05). After treatment, the APACHE Ⅱ score of two groups was significantly lower than that before treatment (P < 0.05), and the APACHE Ⅱ score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the fluid resuscitation dose, antipyretic time, blood pressure recovery time, and complete resuscitation time in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of CRP, IL-18, and ESM-1 in two groups were significantly decreased (P < 0.05), and the serum levels of CRP, IL-18, and ESM-1 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Shenqi Fuzheng Injection combined with Hydrocortisone Injection have the curative effect of sepsis, and can control the development of the disease, promote the recovery of patients, and reduce inflammatory reaction with good safety.
[中圖分類號]
R976
[基金項(xiàng)目]
河南省醫(yī)學(xué)科技攻關(guān)項(xiàng)目(LHGJ20191408)