目的 探討銀花泌炎靈片聯(lián)合氨曲南治療急性尿路感染的臨床效果。方法 選取2018年1月-2021年1月天津市北辰醫(yī)院收治的106例急性尿路感染患者,使用隨機數(shù)字表法分成對照組和治療組,每組各53例。對照組靜脈滴注注射用氨曲南,1.5g加入100mL生理鹽水,2次/d。在對照組基礎(chǔ)上,治療組口服銀花泌炎靈片,4片/次,4次/d。兩組均連續(xù)治療10 d。觀察兩組患者臨床療效,比較治療前后兩組患者尿頻、尿痛、尿急、小腹不適和腰酸痛評分,及尿檢白細胞復(fù)常時間和血清C反應(yīng)蛋白(CRP)水平。結(jié)果 治療后,治療組總有效率為96.2%,較對照組的81.1%顯著升高(P<0.05)。治療后,兩組尿頻、尿痛、尿急、小腹不適和腰酸痛評分均顯著低于本組治療前(P<0.05),且治療組下降更顯著(P<0.05)。治療后,兩組血清CRP水平顯著低于同組治療前(P<0.05),治療組尿檢白細胞復(fù)常時間顯著縮短(P<0.05),血清CRP水平顯著低于對照組(P<0.05)。結(jié)論 銀花泌炎靈片聯(lián)合氨曲南治療急性尿路感染的療效確切,可安全有效地緩解患者尿頻、尿急等癥狀,并能進一步縮短尿檢白細胞復(fù)常時間、減輕機體炎癥反應(yīng)。

Objective To investigate the clinical effect of Yinhua Miyanling Tablets combined with aztreonam in treatment of acute urinary tract infection. Methods Patients (207 cases) with acute urinary tract infection in Tianjin Beichen Hospital from January 2018 to January 2021 were randomly divided into control and treatment group, and each group had 53 cases. Patients in the control group were iv administered with Aztreonam for injection, 1.5 g added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Yinhua Miyanling Tablets on the basis of the control group, 4 tablets/time, four times daily. Patients in two groups were treated for 10 d. After treatment, the clinical evaluation was evaluated, the urinary frequency, urinary pain, urgency, abdominal discomfort and lumbar pain scores, and white blood cell recovery time and serum CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 96.2%, which was significantly higher than 81.1% in the control group (P < 0.05). After treatment, the scores of frequent micturition, urinary pain, urgency, abdominal discomfort and lumbar pain in two groups were significantly lower than those before treatment (P < 0.05), and the decrease was more significant in the treatment group (P < 0.05). After treatment, the level of serum CRP in two groups was significantly lower than that before treatment in the same group (P < 0.05), the recovery time of urine leukocyte in the treatment group was significantly shortened (P < 0.05), and the level of serum CRP in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion The curative effect of Yinhua Miyanling Tablets combined with aztreonam in treatment of acute urinary tract infection is definite, and it can safely and effectively relieve the symptoms such as frequent urination and urgent urination, and further shorten the normalization time of leukocytes in urine test and reduce the inflammatory reaction.

R983