目的 探討腦脈利顆粒聯(lián)合曲克蘆丁治療急性腦梗死臨床療效。方法 選取2019年7月-2021年7月在濮陽市油田總醫(yī)院腦治療的134例急性腦梗死患者,按照隨機數(shù)字表法分為對照組和治療組,每組各67例。對照組靜脈滴注曲克蘆丁注射液, 240 mg溶于5%葡萄糖注射液250 mL中, 1次/d。治療組在對照組基礎(chǔ)上口服腦脈利顆粒, 1袋/次, 3次/d。兩組患者連續(xù)治療7 d。觀察兩組患者臨床療效,比較治療前后兩組患者癥狀好轉(zhuǎn)時間,美國國立衛(wèi)生研究院卒中量表(NIHSS)評分和生活自理能力(BI)評分,血清炎性因子白細胞介素-6(IL-6)、白細胞介素-8(IL-8)、腫瘤壞死因子-α(TNF-α)和超敏C反應(yīng)蛋白(hs-CRP)水平及不良反應(yīng)情況。結(jié)果 治療后,治療組患者總有效率明顯高于對照組(98.51% vs 85.07%,P<0.05)。治療后,治療組臨床癥狀好轉(zhuǎn)時間明顯早于對照組(P<0.05)。治療后,兩組NIHSS評分明顯下降,而BI評分明顯升高(P<0.05),且治療組NIHSS和BI評分明顯好于對照組(P<0.05)。治療后,兩組患者血清炎性因子IL-6、IL-8、TNF-α、CRP水平明顯下降(P<0.05),且治療組血清炎性因子水平明顯低于對照組(P<0.05)。治療組不良反應(yīng)發(fā)生率明顯低于對照組(7.46% vs 14.93%, P<0.05)。結(jié)論 腦脈利顆粒聯(lián)合曲克蘆丁治療可發(fā)揮協(xié)同作用,有助于患者腦神經(jīng)功能的改善,并能降低局部炎癥反應(yīng)。

Objective To explore the clinical effect of Naomaili Granules combined with troxerutin in treatment of acute cerebral infarction.Methods Patients (134 cases) with acute cerebral infarction in Puyang Oilfield General Hospital from July 2019 to July 2021 were randomly divided into control and treatment group, and each group had 67 cases. Patients in the control group were iv administered with Troxerutin Injection, 200 mg added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were po administered with Naomaili Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the improvement time to clinical symptom, the scores of BI and NIHSS, the levels of inflammatory factors IL-6, IL-8, TNF-α, and CRP, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.51% vs 85.07%, P < 0.05). The improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the NIHSS score in two groups were significantly decreased, while the Bi score were significantly increased (P < 0.05), and the scores of the treatment group were significantly better than those of the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-6, IL-8, TNF-α, and CRP in two groups were significantly decreased (P < 0.05), and the levels of serum inflammatory factors in the treatment group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (7.46% vs 14.93%, P < 0.05).Conclusion The combination of Naomaili Granules and troxerutin can improve the function of brain inflammation and reduce the local inflammation of patients.

R971

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