目的 探討乙酰半胱氨酸聯(lián)合頭孢唑肟治療新生兒肺炎的臨床療效。方法 選擇2019年4月-2021年4月在南陽(yáng)市中心醫(yī)院治療的96例新生兒肺炎患者,依據(jù)用藥不同分成對(duì)照組和治療組,每組各48例。對(duì)照組靜脈滴注注射用頭孢唑肟鈉, 50 mg/kg加入15 mL生理鹽水, 1次/8 h;治療組在對(duì)照組基礎(chǔ)上霧化吸入吸入用乙酰半胱氨酸溶液, 3 mL/次, 2次/d。兩組均經(jīng)10 d治療。觀察兩組患兒臨床療效,比較治療前后兩組患兒臨床癥狀改善時(shí)間,及血清炎癥因子C反應(yīng)蛋白(CRP)、降鈣素原(PCT)和白細(xì)胞介素-6(IL-6)水平。結(jié)果 經(jīng)治療,對(duì)照組和治療組有效率分別為83.33%、97.92%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。經(jīng)治療,治療組患兒臨床癥狀改善時(shí)間均明顯早于對(duì)照組(P<0.05)。經(jīng)治療,兩組患兒血清炎癥因子CRP、PCT和IL-6水平均明顯下降(P<0.05),且治療組患兒明顯低于對(duì)照組(P<0.05)。結(jié)論 乙酰半胱氨酸聯(lián)合頭孢唑肟治療新生兒肺炎可有效改善患兒臨床癥狀,促進(jìn)機(jī)體炎癥因子水平下降,有利于患兒肺通氣肺換氣功能改善。

Objective To investigate the effects of acetylcysteine combined with cefazoxime in treatment of neonatal pneumonia.Methods Newborn (96 cases) with pneumonia in Nanyang Central Hospital from April 2019 to April 2021 were divided into control and treatment group based on different treatments, and each group had 48 cases. Newborn in the control group were iv administered with Ceftizoxime Sodium for injection, 50 mg/kg added into normal saline 15 mL, once every 8 h. Newborn in the treatment group were atomization inhalation administered with Acetylcysteine Solution for inhalation on the basis of the control group, 3 mL/time, twice daily. Newborn in two groups were treated for 10 d. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, the levels of inflammatory mediators CRP, PCT and IL-6 in two groups before and after treatment were compared.Results After treatment, the effective rates of the control group and the treatment group were 83.33% and 97.92% respectively (P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the serum inflammatory factors CRP, PCT and IL-6 in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion Acetylcysteine combined with cefazoxime in treatment of neonatal pneumonia can effectively improve the clinical symptoms, reduce the level of inflammatory factors, and improve the pulmonary ventilation function.

R974;R985

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃聯(lián)合項(xiàng)目(LHGJ20200649)