目的 探討西甲硅油聯(lián)合奧美拉唑治療兒童功能性消化不良的臨床療效。方法 選取2020年3月-2021年3月鄭州大學(xué)第三附屬醫(yī)院收治的100例功能性消化不良兒童。隨機(jī)分為對(duì)照組(50例)和治療組(50例)。對(duì)照組餐前30 min口服奧美拉唑腸溶膠囊,0.6~1.0 mg/(kg?d),1次/d。治療組在對(duì)照組基礎(chǔ)上口服西甲硅油乳劑,1~2 mL/次,3~5次/d。兩組患兒連續(xù)用藥4周。觀察兩組患兒臨床療效,比較治療前后兩組患兒臨床癥狀緩解時(shí)間和不同時(shí)間胃排空率。結(jié)果 用藥2周后,對(duì)照組臨床有效率為54.5%,顯著低于治療組的78.3%(P<0.05);用藥4周后,對(duì)照組臨床有效率為68.2%,顯著低于治療組的87.0%(P<0.05)。治療過程中,治療組癥狀緩解時(shí)間均明顯早于對(duì)照組(P<0.05)。治療2、4周后,兩組胃排空率均高于治療前(P<0.05),治療組胃排空功能指標(biāo)較對(duì)照組改善更為顯著(P<0.05)。結(jié)論 西甲硅油聯(lián)合奧美拉唑能快速改善兒童功能性消化不良,并能持續(xù)緩解,安全性及耐受性好。

Objective To investigate clinical effect of simethicone combined with omeprazole in treatment of children with functional dyspepsia.Methods Children (100 cases) with functional dyspepsia in the Third Affiliated Hospital of Zhengzhou University from March 2020 to March 2021 were randomly divided into control (50 cases) and treatment (50 cases) group. Children in the control group were po administered with Omeprazole Enteric-coated Capsules, 0.6 — 1.0 mg/(kg?d), once daily. Children in the treatment group were po administered with Simethicone Emulsion on the basis of the control group, 1 — 2 mL/time, 3 — 5 times/d. Children in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, the gastric emptying rate of different time in two groups before and after treatment were compared.Results After 2 weeks of treatment, the clinical effective rate of control group was 54.5%, significantly lower than 78.3% of treatment group (P < 0.05). After 4 weeks of treatment, the clinical effective rate in control group was 68.2%, significantly lower than 87.0% in treatment group (P < 0.05). During the treatment, the time of symptom relief in the treatment group was significantly earlier than that in the control group (P < 0.05). After 2 and 4 weeks of treatment, the gastric empty-rate in both groups was higher than before (P < 0.05); the improvement of gastric emptying function in the treatment group was more significant than that in the control group (P < 0.05).Conclusion Simethicone Emulsion combined with omeprazole can quickly improve the functional dyspepsia of children, and can continuously relieve with good safety and tolerance.

R975;R985

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃(聯(lián)合共建)項(xiàng)目(LHGJ20190404)