早泄是在男性群體中普遍存在的疾病,其治療藥物主要分為局部外用藥物和口服藥物。表面麻醉劑具有良好的療效、最小的全身副作用并且可以"按需"使用,是治療早泄的首選藥物之一。局部共晶混合物利丙雙卡因噴霧劑是用于早泄治療的審批通過藥物。表面麻醉劑治療早泄的標簽外使用藥物包括利丙雙卡因乳膏、Stud-100噴霧劑、Promescent噴霧劑和SS霜。通過表面麻醉劑聯合5型磷酸二酯酶抑制劑、5-羥色胺再攝取抑制劑、中藥制劑還可以提高臨床療效?？偨Y了治療早泄的表面麻醉劑的研究進展,為臨床用藥和新藥研發(fā)提供思路。

Premature ejaculation is a common disease in men, and its treatment drugs are mainly divided into topical drugs and oral drugs. Topical anesthetics have good efficacy, minimal systemic side effects, and can be used "on demand", and are one of the drugs of choice for treatment of premature ejaculation. Topical eutectic mixture Lidocaine and Prilocaine Spray is an approved medication for the treatment of premature ejaculation. Off-label topical anaesthetics for premature ejaculation include Lidocaine and Prilocaine Cream, Stud-100 Spray, Promescent Spray, and SS Cream. Topical anesthetics combined with phosphodiesterase type 5 inhibitors, serotonin reuptake inhibitors, and traditional Chinese medicine preparations can also improve clinical efficacy. This paper summarizes the research progress on topical anesthetics for the treatment of premature ejaculation, and provides ideas for clinical drug use and new drug development.

R977;R985

國家科技重大專項課題重大新藥創(chuàng)制項目(2017ZX09301025);貴州省科技計劃項目(黔科合支撐[2021]一般476)