塞來昔布是一種特異性環(huán)氧化酶-2抑制劑，具有抗炎、鎮(zhèn)痛和退熱作用。近年來，塞來昔布的抗腫瘤作用受到廣泛關(guān)注，已被應(yīng)用于消化道腫瘤、乳腺癌、肺癌、肝癌、前列腺癌等的化學(xué)輔助治療和放射治療增敏。綜述了塞來昔布的抗腫瘤效應(yīng)，并總結(jié)了其作用機(jī)制，如抑制腫瘤細(xì)胞增殖、抑制腫瘤細(xì)胞侵襲和轉(zhuǎn)移、抑制腫瘤新生血管生成、誘導(dǎo)腫瘤細(xì)胞分化、誘導(dǎo)腫瘤細(xì)胞凋亡、調(diào)節(jié)腫瘤免疫、逆轉(zhuǎn)腫瘤細(xì)胞的多藥耐藥性，以期為塞來昔布的深入研究和臨床腫瘤防治提供用藥參考。

Celecoxib is a specific cyclooxygenase-2 inhibitor, and has anti-inflammatory, analgesic, and antipyretic effects. In recent years, the antitumor effect of celecoxib has received extensive attention, and has been applied to adjuvant chemotherapy and radiotherapy for gastrointestinal cancer, breast cancer, lung cancer, liver cancer, prostate cancer, and so on. This article reviews the antitumor effect of celecoxib and summarizes its mechanism, such as inhibiting tumor cell proliferation, inhibiting tumor cell invasion and metastasis, inhibiting tumor angiogenesis, inducing tumor cell differentiation, inducing tumor cell apoptosis, regulating tumor immunity, and reversing multidrug resistance of tumor cells, in order to provide drug reference for further research and clinical tumor prevention and treatment of celecoxib.

R979.1

國家自然科學(xué)基金資助項(xiàng)目(81803101);天津市自然科學(xué)基金資助項(xiàng)目(19JCQNJC12300)