蘆薈大黃素為蒽醌類化合物，主要來源于蘆薈、大黃、巴天酸模、山扁豆等植物中，具有良好的抗菌、瀉下作用。近年來，研究者在對(duì)蘆薈大黃素藥理活性的研究中發(fā)現(xiàn)其有巨大的抗腫瘤潛力。從誘導(dǎo)腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞增殖、抑制腫瘤細(xì)胞侵襲和轉(zhuǎn)移、誘導(dǎo)腫瘤細(xì)胞自噬、抗炎、免疫調(diào)節(jié)方面對(duì)蘆薈大黃素的抗腫瘤作用機(jī)制進(jìn)行綜述，為其進(jìn)一步的應(yīng)用、開發(fā)提供參考。

Aloe-emodin is an anthraquinone compound, mainly from Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg., Rheum officinale Baill., Rumex patientia Linn., Cassia mimosoides L. and other plants, with good antibacterial and laxative effects. In recent years, researchers have found that aloe-emodin has great anti-tumor potential in its study of the pharmacological activity. This article reviews the anti-tumor mechanisms of aloe-emodin, such as inducing tumor cell apoptosis, inhibiting tumor cell proliferation, inhibiting tumor cell invasion and metastasis, inducing tumor cell autophagy, anti-inflammatory, and immune regulation, to provide reference for its further application and development.

R979.1

國(guó)家自然科學(xué)基金資助項(xiàng)目(81760491);廣西科學(xué)技術(shù)廳科技開發(fā)項(xiàng)目(桂科攻1355004-8);廣西醫(yī)療衛(wèi)生適宜技術(shù)開發(fā)與推廣應(yīng)用項(xiàng)目(S2020106);2022年度廣西高校中青年教師科研基礎(chǔ)能力提升項(xiàng)目(2022KY0502);桂林市科學(xué)研究與技術(shù)開發(fā)計(jì)劃項(xiàng)目(20210227-8-7)