神經病理性疼痛是由神經系統(tǒng)原發(fā)性損害和功能障礙所激發(fā)或引起的疼痛，炎癥作為神經病理性疼痛發(fā)展的重要病機之一，是生物體對組織損傷做出的一種正常生理反應。炎癥介導的神經病理性疼痛發(fā)展機制與外周神經敏化、中樞神經敏化息息相關，包括神經炎癥反應、氧化應激反應、離子通道改變、膠質細胞的活化。常見的中藥成分馬錢子堿、小檗堿、去氫紫堇鱗莖堿、川芎嗪、氧化苦參堿、青藤堿均可緩解神經病理性疼痛。生物堿可通過多條途徑影響神經病理性疼痛，其發(fā)揮的抗炎作用影響著外周神經敏化和中樞神經敏化，是治療神經病理性疼痛的重要機制之一。因此生物堿介導的炎癥反應具有良好的抗神經元損傷作用，對神經病理性疼痛產生一定的治療作用?？偨Y了炎癥參與神經病理性疼痛和生物堿抗炎鎮(zhèn)痛的機制，擬從分子層面闡釋生物堿發(fā)揮抗神經病理性疼痛的作用機制。

Neuropathic pain is motivated and caused by primary damage and dysfunction of the nervous system. As one of the important pathogenesis of neuropathic pain, inflammation is a normal physiological response of organisms to tissue damage. The mechanism of inflammation-mediated neuropathic pain development is closely related to peripheral nerve sensitization and central nerve sensitization, including neuroinflammation, oxidative stress, changes in ion channels, and activation of glial cells. The common traditional Chinese medicine active components, such as strychnine, berberine, dehydrovioletine, ligustrazine, oxymatrine, and sinomenine can relieve neuropathic pain. Alkaloids can affect neuropathic pain through multiple pathways, and their anti- inflammatory effects affect peripheral nerve sensitization and central nerve sensitization, and it is one of the important mechanisms for the treatment of neuropathic pain. Therefore, alkaloid-mediated inflammatory response has good anti-neuron damage and has a certain therapeutic effect on neuropathic pain. This paper summarizes the mechanism of inflammation involved in neuropathic pain and alkaloids anti-inflammatory and analgesic, and intends to elucidate the mechanism of alkaloids exerting anti-neuropathic pain at the molecular level.

R971

貴州中醫(yī)藥大學第二附屬醫(yī)院院內科研項目(GZEYK[2020]13號)