目的 探討痹祺膠囊聯(lián)合鹽酸替扎尼定片治療椎動脈型頸椎病的臨床療效。方法 選取2020年5月—2021年9月鄭州大學(xué)附屬鄭州中心醫(yī)院收治的112例椎動脈型頸椎病患者，根據(jù)隨機數(shù)字表法將112例患者分為對照組和治療組，每組各56例。對照組口服鹽酸替扎尼定片，2 mg/次，3次/d；治療組在對照組基礎(chǔ)上口服痹祺膠囊，1.2 g/次，3次/d。兩組連續(xù)治療4周。觀察兩組臨床療效，比較兩組疼痛程度、基底動脈的血流速率（V_m）、動脈收縮期峰值流速（PSV）、血管阻力指數(shù)（RI）及血清內(nèi)皮素-1（ET-1）、白細(xì)胞介素-1β（IL-1β）、一氧化氮（NO）水平。結(jié)果 治療后，治療組患者的總有效率（94.6%）明顯高于對照組（82.1%），差異有統(tǒng)計學(xué)意義（P＜0.05）。治療后，兩組患者數(shù)字疼痛強度量表（NRS）評分較治療前顯著降低（P＜0.05）；治療組的NRS評分明顯低于對照組（P＜0.05）。治療后，兩組的基底動脈V_m、PSV高于治療前，RI低于治療前（P＜0.05）；治療后治療組的基底動脈V_m、PSV比對照組高，RI比對照組低（P＜0.05）。治療后，兩組的血清ET-1、IL-1β、NO水平明顯降低（P＜0.05）；治療組的ET-1、IL-1β、NO水平比對照組低（P＜0.05）。結(jié)論 痹祺膠囊聯(lián)合鹽酸替扎尼定片可提高椎動脈型頸椎病的療效，能夠降低疼痛程度，改善血流動力學(xué)水平，調(diào)節(jié)血清ET-1、IL-1β、NO水平，安全性良好。

Objective To investigate the clinical efficacy of Biqi Capsules combined with Tizanidine Hydrochloride Tablets in treatment of cervical spondylosis of vertebral artery type. Methods Patients (112 cases) with cervical spondylosis of vertebral artery type in Zhengzhou Central Hospital Affiliated to Zhengzhou University from May 2020 to September 2021 were divided into control and treatment groups according to the random number table method, and each group had 56 cases. Patients in the control group were po administered with Tizanidine Hydrochloride Tablets, 2 mg/time, three times daily. Patients in the treatment group were po administered with Biqi Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the degree of pain, V_m, PSV, and RI of basilar artery, the serum levels of ET-1, NO, and IL-1β in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.6%) was significantly higher than that of the control group (82.1%) (P < 0.05). After treatment, the NRS score of two groups was significantly lower than that before treatment (P < 0.05), and the NRS score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, V_m and PSV of basilar artery in two groups were higher than those before treatment, but RI in two groups was lower than that before treatment (P < 0.05). After treatment, V_m and PSV of basilar artery in the treatment groupwere higher than those in the control group, but RI in the treatment group was lower than those in the control group (P < 0.05). After treatment, the levels of ET-1, IL-1β, and NO in two groups were significantly decreased (P < 0.05), and the levels of ET-1, IL-1β, and NO in the treatment group were lower than those in the control group (P < 0.05). Conclusion Biqi Capsules Combined with Tizanidine Hydrochloride Tablets can improve the therapeutic effect of cervical spondylosis of vertebral artery type, reduce the degree of pain, improve the level of hemodynamics, and regulate the serum levels of ET-1, IL-1 and NO, with good safety.

R971

河南省中醫(yī)藥科學(xué)研究專項課題(019ZY2090)