目的 探討孕康糖漿聯(lián)合烯丙雌醇片治療先兆流產的臨床療效。方法 選取2019年10月—2021年10月在汝州市第一人民醫(yī)院就診的138例先兆流產患者，按照隨機數字表法將所有患者分為對照組和治療組，每組各69例。對照組口服烯丙雌醇片，孕周6～8周，5 mg/次，1次/12 h；孕周9～12周，10 mg/次，1次/12 h。治療組在對照組基礎上口服孕康糖漿，20 mL/次，3次/d。兩組連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組癥狀的消失時間和血清中β人絨毛膜促性腺激素（β-HCG）、泌乳素（PRL）、妊娠相關蛋白A（PAPP-A）、激活素A、抑制素A、糖類抗原125（CA125）水平。結果 治療后，治療組患者的總有效率為95.65%，對照組的總有效率為84.06%，組間有明顯差異（P＜0.05）。治療后，治療組陰道出血、下腹痛、腰酸脹痛消失時間比對照組短，差異有統(tǒng)計學意義（P＜0.05）。治療后，兩組的β-HCG、PRL、PAPP-A水平顯著升高（P＜0.05），治療組β-HCG、PRL、PAPP-A水平顯著高于對照組，差異有統(tǒng)計學意義（P＜0.05）。治療后，兩組的血清激活素A、抑制素A水平明顯升高，CA125水平明顯降低（P＜0.05）；治療后治療組的血清激活素A、抑制素A水平高于對照組，CA125水平低于對照組，差異有統(tǒng)計學意義（P＜0.05）。結論 孕康糖漿聯(lián)合烯丙雌醇片可提高先兆流產的臨床療效，有助于進一步減輕臨床癥狀，調節(jié)激素水平，調節(jié)激活素A、抑制素A、CA125水平，安全性較好。

Objective To investigate the therapeutic effect of Yunkang Syrup combined with Allylestrenol Tablets in treatment of threatened abortion. Methods Patients (138 cases) with threatened abortion in the First People's Hospital of Ruzhou from October 2019 to October 2021 were randomly divided into control and treatment groups, and each group had 69 cases. Patients in the control group were po administered with Allylestrenol Tablets, pregnant weeks:6-8 weeks, 5 mg/time, every 12 h, pregnant weeks:9-12 weeks, 10 mg/time, every 12 h. Patients in the treatment group were po administered with Yunkang Syrup on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the disappearance time of symptoms, the serum levels of β-hCG, PRL, PAPP-A, activin A, inhibin A, and CA125 in two groups were compared. Results After treatment, the total effective rate was 95.65% in the treatment group, 84.06% in the control group, and there was significant difference between the groups (P < 0.05). After treatment, the disappearance time of vaginal bleeding, lower abdominal pain, and low back pain in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the levels of β-hCG, PRL, and PAPP-A in two groups were significantly increased (P < 0.05). And the levels of β-hCG, PRL, and PAPP-A in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, activin A and inhibin A in two groups were significantly increased, but the level of CA125 were significantly decreased (P < 0.05). After treatment, the levels of activin A and inhibin A in the treatment group were higher than those in the control group, but the level of CA125 was lower than that in the control group (P < 0.05). Conclusion Yunkang Syrup combined with Allylestrenol Tablets can improve the clinical efficacy of threatened abortion, help to further reduce clinical symptoms, regulate hormone levels, and regulate the levels of activin A, inhibin A and CA125, with good safety.

R984

安陽市重點研發(fā)與推廣專項(2022C01SF049)