目的 分析2019—2021年復旦大學附屬婦產科醫(yī)院住院患者低分子肝素的使用情況，并評價其合理性，為婦產科低分子肝素合理性使用提供數據資料。方法 采用回顧性研究方法，從復旦大學附屬婦產科醫(yī)院住院醫(yī)院信息系統(tǒng)（HIS）中查詢2019年1月—2021年12月使用低分子肝素的病史信息，包含患者年齡、科室、出入院診斷、手術名稱、藥品名稱及規(guī)格、使用頻次、單次劑量和給藥途徑等。結果 2019—2021年使用低分子肝素的患者共54 138例，其中產科14 068例，婦科40 070例。產科年齡分布在19～35歲，婦科年齡分布在41～60歲。診斷為靜脈血栓栓塞的患者共102例，婦科患者居多，占比90.20%。預防用藥方面，產科剖宮產患者居多，占比63.25%；婦科為手術患者，占比98.06%，婦科惡性腫瘤的患者占比26.28%。產科及婦科患者預防用藥和治療性用藥療程主要集中在1～7 d，不合理的用法用量主要表現為給藥途徑不合理、單次劑量超限和給藥頻次不合理等，共64例，占比0.12%。結論 2019—2021年復旦大學附屬婦產科醫(yī)院低分子肝素的使用以預防使用為主。產科以剖宮產患者為主，婦科以手術患者為主，用法用量基本合理。

Objective To analyze the use of low molecular weight heparin in inpatients of Obstetrics and Gynecology Hospital Affiliated to Fudan University from 2019 to 2021, and evaluate its rationality, providing data for rational use of low molecular weight heparin in obstetrics and gynecology. Methods Using retrospective study method, from the department of Obstetrics and Gynecology Hospital Affiliated to Fudan University (HIS) query from January 2019 to December 2021 history of low molecular weight heparin information, include patients' age, department, diagnosis, surgery, descriptions, and specifications of drugs, frequency of usage, the single dose and method, etc. Results A total of 54 138 patients received low molecular weight heparin from 2019 to 2021, including 14 068 in obstetrics and 40 070 in gynecology. The obstetrical age ranged from 19 to 35 years, and the gynecological age ranged from 41 to 60 years. A total of 102 patients were diagnosed as venous thromboembolism, most of which were gynecological patients, accounting for 90.20%. In terms of prophylactic drugs, the majority of patients were caesarean section, accounting for 63.25%, gynecological surgery patients accounting for 98.06%, gynecological malignant tumor patients accounted for 26.28%. The prophylactic and therapeutic medication courses of obstetrics and gynecology patients mainly focus on 1 to 7 d. Unreasonable usage and dosage were mainly manifested as irrational administration route, single dose exceeding limit, and irrational administration frequency, 64 cases in total, accounting for 0.12%. Conclusion The use of low molecular weight heparin in Obstetrics and Gynecology Hospital Affiliated to Fudan University from 2019 to 2021 was mainly preventive. Obstetrics to cesarean delivery patients, gynecology to surgery patients, the usage and dosage is basically reasonable.

R972

上海市"醫(yī)苑新星"青年醫(yī)學人才培養(yǎng)資助計劃(滬衛(wèi)計人事[2019]72號)