目的 調(diào)查2021年遂寧市中心醫(yī)院住院患者臨床應(yīng)用利伐沙班的合理性，為臨床合理用藥提供參考。方法 回顧性調(diào)查分析遂寧市中心醫(yī)院2021年1月—12月住院患者使用利伐沙班抗凝的病例共2 405份，對(duì)其應(yīng)用的適應(yīng)癥、禁忌癥、用法用量、用藥時(shí)機(jī)、用藥療程、藥物轉(zhuǎn)換的合理性進(jìn)行分析。結(jié)果 2 405例應(yīng)用利伐沙班的病歷中，適應(yīng)癥不合理306例，存在用藥禁忌84例；2 099例具有應(yīng)用利伐沙班適應(yīng)癥的病歷中，用法用量不合理741例，給藥時(shí)機(jī)不合理15例，療程不合理31例，藥物轉(zhuǎn)換不合理104例。結(jié)論 遂寧市中心醫(yī)院住院患者應(yīng)用利伐沙班主要存在無適應(yīng)癥用藥、用法用量不合理等用藥現(xiàn)象，應(yīng)加強(qiáng)宣教。

Objective To investigate the application of rivaroxaban for inpatients in Suining Central Hospital in 2021, and provide references for clinical rational drug use. Methods A total of 2 405 cases of rivaroxaban anticoagulation in inpatients in Suining Central Hospital from January to December 2021 were retrospectively analyzed, and the indications, contraindications, usage and dosage, timing of administration, duration of administration and rationality of drug conversion were analyzed. Results Among 2 405 cases of rivaroxaban, there were 306 cases of unreasonable indications and 84 cases of contraindication. Among the 2 099 medical records with indications for the use of rivaroxaban, there were 741 cases in unreasonable usage and dosage, 15 cases in unreasonable medication time, 31 cases in unreasonable course of treatment, and 104 cases in unreasonable drug conversion. Conclusion Inpatients using rivaroxaban mainly suffer from irrational use of drugs without indications, unreasonable usage and dosage, etc. Therefore, publicity and education should be strengthened.

R972