有機(jī)陽離子轉(zhuǎn)運(yùn)體家族是一類位于細(xì)胞膜上的功能性膜蛋白，負(fù)責(zé)轉(zhuǎn)運(yùn)內(nèi)源性、外源性陽離子底物，在底物的吸收、分布和排泄過程中發(fā)揮著重要作用，其中肝臟、腎臟和消化道處有機(jī)陽離子轉(zhuǎn)運(yùn)體的作用最明顯。在疾病狀態(tài)下有機(jī)陽離子轉(zhuǎn)運(yùn)體的表達(dá)和功能會(huì)發(fā)生改變，會(huì)影響底物的體內(nèi)處置過程，使底物的動(dòng)力學(xué)行為及其效應(yīng)發(fā)生改變。綜述了肝臟疾病、腎臟疾病和消化道疾病狀態(tài)下有機(jī)陽離子轉(zhuǎn)運(yùn)體表達(dá)和功能改變對(duì)底物體內(nèi)轉(zhuǎn)運(yùn)的影響及其生理、藥理學(xué)意義。

The family of organic cation transporters (OCTs), located on the cell membrane, is a class of functional membrane proteins and responsible for transporting endogenous/exogenous cation substrates, and play an important role in the absorption, distribution, and excretion of substrates and OCTs account for salient contribution to substrate transport in the liver, kidney, and digestive tract. The expression and function of OCTs, altered in pathological state, can affect the in vivo disposition of substrates and influence the kinetic process and their effects. This review summarizes the impact of changes in the expression and function of OCTs on substrate transport and their physiological/pharmacological significance in the liver, kidney, and digestive tract diseases.

R966

國家自然科學(xué)基金資助項(xiàng)目(82173884)