竹節(jié)香附素A是兩頭尖中主要含有的三萜皂苷，具有較強的抗腫瘤活性。竹節(jié)香附素A可抑制腫瘤細胞增殖，誘導(dǎo)其凋亡和自噬；誘導(dǎo)腫瘤細胞周期阻滯；抑制侵襲和轉(zhuǎn)移；增強腫瘤細胞對化療藥物的敏感性?？偨Y(jié)了竹節(jié)香附素A的抗腫瘤作用機制，以期為竹節(jié)香附素A的開發(fā)利用和臨床應(yīng)用提供依據(jù)。

Raddeanin A is a main triterpenoid saponin contained in Anemones Raddeanae Rhizoma and has strong anti-tumor activity. Raddeanin A can inhibit tumor cell proliferation, induce apoptosis and autophagy, induce tumor cell cycle arrest, inhibit invasion and metastasis, enhance tumor cell sensitivity to chemotherapeutic drugs. This paper summarizes the anti-tumor mechanism of raddeanin A, in order to provide the basis for the development, utilization, and clinical application of raddeanin A.

R979.1

國家自然科學(xué)基金青年基金資助項目(81703582);湖北省自然科學(xué)基金資助項目(2016CFB153,2020CFB713);湖北省衛(wèi)生健康科研基金資助項目(WJ2019M057)