目的 探討參苓白術(shù)顆粒聯(lián)合奧替溴銨片治療腸易激綜合征的臨床療效。方法 選擇2020年3月—2021年11月漯河市醫(yī)學(xué)高等專(zhuān)科學(xué)校第二附屬醫(yī)院消化內(nèi)科收治的100例腸易激綜合征患者，按隨機(jī)數(shù)字表法將100例患者分為對(duì)照組和治療組，每組各包括50例。對(duì)照組患者口服奧替溴銨片，1片/次，3次/d。治療組在對(duì)照組基礎(chǔ)上溫水沖服參苓白術(shù)顆粒，1袋/次，3次/d。兩組患者共治療8周。觀(guān)察兩組的臨床療效，比較兩組的癥狀消失時(shí)間、病情程度、血清過(guò)氧化還原酶1（PRDX1）、白細(xì)胞介素-13（IL-13）、腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，治療組的總有效率為94.00%，對(duì)照組的總有效率為78.00%，組間比較差異顯著（P＜0.05）。治療后，治療組患者腹痛、腹瀉、腹脹消失時(shí)間均短于對(duì)照組（P＜0.05）。治療后，兩組的腸易激綜合征癥狀嚴(yán)重度量表（IBS-SSS）腹痛程度、排便滿(mǎn)意度、腹部不適、腹痛頻次、生活影響評(píng)分均低于治療前（P＜0.05），且治療組的IBS-SSS各項(xiàng)評(píng)分均明顯低于對(duì)照組（P＜0.05）。治療后，兩組的血清IL-13水平高于治療前，血清PRDX1、TNF-α水平低于治療前（P＜0.05）；治療組的血清IL-13水平高于對(duì)照組，血清PRDX1、TNF-α水平低于對(duì)照組（P＜0.05）。結(jié)論 參苓白術(shù)顆粒聯(lián)合奧替溴銨片治療腸易激綜合征的療效確切，能控制病情程度，減輕炎癥反應(yīng)，并且安全性良好。

Objective To investigate the clinical efficacy of Shenling Baizhu Granules combined with Otionium Bromide Tablets in treatment of irritable bowel syndrome. Methods Patients (100 cases) with irritable bowel syndrome in the Second Affiliated Hospital of Luohe Medical College from March 2020 to November 2021 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Otionium Bromide Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Shenling Baizhu Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance time of symptom, the degree of illness, and the serum levels of PRDX1, IL-13, and TNF-α in two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.00%, that of the control group was 78.00%,, and there was significant difference between the groups (P < 0.05). After treatment, the disappearance time of abdominal pain, diarrhea, and abdominal distension in the treatment group was lower than that in the control group (P < 0.05). After treatment, the scores of abdominal pain, defecation satisfaction, abdominal discomfort, abdominal pain frequency, and life impact of IBS-SSS in two groups were lower than those before treatment (P < 0.05), and the scores of abdominal pain, defecation satisfaction, abdominal discomfort, abdominal pain frequency, and life impact of IBS-SSS in the treatment group were significantly lower than those in the control group (P < 0.05).>After treatment, the serum levels of IL-13 in two groups were higher than those before treatment, but the serum levels of PRDX1 and TNF-α were lower than those before treatment (P < 0.05). The levels of serum IL-13 in the treatment group were higher than those in the control group, but the serum levels of PRDX1 and TNF-α were lower than those in the control group (P < 0.05).Conclusion Shenling Baizhu Granules combined with Otionium Bromide Tablets is effective in treatment of irritable bowel syndrome, can control the degree of illness, and reduce inflammatory reaction, with good safety.

R975

開(kāi)封市科技發(fā)展計(jì)劃項(xiàng)目(1603083)