目的 探討消糜栓與氟康唑片聯(lián)合治療念珠菌性陰道炎的臨床療效。方法 選擇2021年2月—2021年8月在濮陽市油田總醫(yī)院治療的97例念珠菌性陰道炎患者，隨機分為對照組（49組）和治療組（48組）。對照組患者口服氟康唑片，150 mg/次，1次/d。在對照組的基礎(chǔ)上，治療組陰道給予消糜栓，1粒/次，1次/d。兩組用藥7 d觀察治療效果。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時間，血清白細胞介素-6（IL-6）、γ干擾素（IFN-γ）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組臨床有效率為97.91%，明顯高于對照組的81.63%（P＜0.05）。經(jīng)治療，治療組癥狀改善時間均明顯早于對照組（P＜0.05）。治療后，兩組患者血清IL-6、IFN-γ、TNF-α、CRP水平均明顯降低（P＜0.05）；且治療組IL-6、IFN-γ、TNF-α、CRP水平均明顯低于對照組（P＜0.05）。治療組不良反應(yīng)發(fā)生率為6.25%，明顯低于對照組的14.29%（P＜0.05）。結(jié)論 對于念珠菌性陰道炎治療，采用氟康唑片與消糜栓治療效果確切，并可以調(diào)節(jié)血清炎性因子水平，能有效降低復(fù)發(fā)率，且安全有效。

Objective To investigate the efficacy of Xiaomi Suppository combined with fluconazole in treatment of candidal vaginitis. Methods Patients (97 cases) with candidal vaginitis in Puyang Oilfield General Hospital from February 2021 to August 2021 were randomly divided into control (49 cases) and treatment (48 cases) group. Patients in the control group were po administered with Fluconazole Tablets, 150 mg/time, once daily. Patients in the treatment group were vaginally administered with Xiaomi Suppository on the basis of the control group, 1 grain/time, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, the levels of serum IL-6, IFN-γ, TNF-α and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.91%, significantly higher than 81.63% of the control group (P < 0.05). After treatment, the improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of serum IL-6, IFN-γ, TNF-α, CRP in two groups were significantly reduced (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was 6.25%, which was significantly lower than 14.29% in the control group (P < 0.05). Conclusion Fluconazole Tablets combined with Xiaomi Suppository is effective in the treatment of candidal vaginitis, which can regulate the level of serum inflammatory factors, effectively reduce the recurrence rate, and is safe and effective.

R984

河南省科學技術(shù)項目(9412011Y1064)